Document Detail


Impact of hypercholesterolemia on toxicity of N-nitrosodiethylamine: biochemical and histopathological effects.
MedLine Citation:
PMID:  16845216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-nitrosodiethylamine (NDEA) is an important carcinogen frequently present in human environment and food chain. Nitrosamines such as NDEA produce oxidative stress due to generation of reactive oxygen species and alter the antioxidant defence system in the tissues. The present investigation was aimed at studying its toxicity under hypercholesterolemic conditions. NDEA administration brought about hepatic degeneration as evidenced by the significant decrease in liver weight index of both normal as well as hypercholesterolemic animals. Hypercholesterolemia did not affect the hemoglobin (Hb) content in experimental animals but resulted in an increase in the osmotic fragility of erythrocytes. The antioxygenic potential of experimental animals decreased in both, the NDEA-fed group as well as in the group that was also supplemented with a hypercholesterolemic diet. This was evident by increased in vitro lipid peroxidation (LPO) of erythrocytes. Administration of NDEA resulted in a substantial and significant increase in LPO in all the tissues under normal as well as hypercholesterolemic conditions. Addition of hypercholesterolemic diet in general, increased LPO in all the tissues to varying degrees but its effect was maximal in the liver. Effect of NDEA administration on antioxygenic enzymes under normal as well as hypercholesterolemic conditions was variable in different tissues. Histopathological analysis of different tissues (heart, liver, lungs, spleen and kidneys) showed mild to severe pathological changes among the control and experimental groups.
Authors:
Gaurav Mittal; Apminder Pal Singh Brar; Giridhar Soni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  58     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-07-17     Completed Date:  2006-12-28     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry & Chemistry, Punjab Agricultural University, Ludhiana 141 004, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / toxicity*
Catalase / metabolism
Cholesterol, Dietary / pharmacology
Diethylnitrosamine / toxicity*
Eating / drug effects
Hypercholesterolemia / physiopathology*
Kidney / drug effects,  pathology
Lipid Peroxidation / drug effects
Liver / drug effects*,  metabolism,  pathology
Lung / drug effects,  pathology
Male
Organ Size / drug effects
Osmotic Fragility / drug effects
Oxidative Stress / drug effects
Peroxidase / metabolism
Rats
Spleen / drug effects,  pathology
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Cholesterol, Dietary; 55-18-5/Diethylnitrosamine; EC 1.11.1.6/Catalase; EC 1.11.1.7/Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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