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Impact of human herpes virus 6 in liver transplantation.
MedLine Citation:
PMID:  21161019     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Human herpes virus 6 (HHV-6) infects > 95% of humans. Primary infection which occurs mostly during the first 2 years of life in the form of roseola infantum, non-specific febrile illness, or an asymptomatic illness, results in latency. Reactivation of latent HHV-6 is common after liver transplantation. Since the majority of human beings harbor the latent virus, HHV-6 infections after liver transplantation are most probably caused by endogenous reactivation or superinfection. In a minority of cases, primary HHV-6 infection may occur when an HHV-6-seronegative individual receives a liver allograft from an HHV-6-seropositive donor. The vast majority of HHV-6 infections after liver transplantation are asymptomatic. Only in a minority of cases, when HHV-6 causes a febrile illness associated with rash and myelosuppression, hepatitis, gastroenteritis, pneumonitis, and encephalitis after liver transplantation. In addition, HHV-6 has been implicated in a variety of indirect effects, such as allograft rejection and increased predisposition to and severity of other infections, including cytomegalovirus, hepatitis C virus, and opportunistic fungi. Because of the uncommon nature of the clinical illnesses directly attributed to HHV-6, there is currently no recommended HHV-6-specific approach prevention after liver transplantation. Asymptomatic HHV-6 infection does not require antiviral treatment, while treatment of established HHV-6 disease is treated with intravenous ganciclovir, foscarnet, or cidofovir and this should be complemented by a reduction in immunosuppression.
Authors:
Raymund R Razonable; Irmeli Lautenschlager
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of hepatology     Volume:  2     ISSN:  1948-5182     ISO Abbreviation:  World J Hepatol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101532469     Medline TA:  World J Hepatol     Country:  China    
Other Details:
Languages:  eng     Pagination:  345-53     Citation Subset:  -    
Affiliation:
Raymund R Razonable, Division of Infectious Diseases, Department of Medicine, and the William J von Liebig Transplant Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
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