Document Detail


Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations.
MedLine Citation:
PMID:  22886787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian-European SLE patients.
METHODS: A total of 2,116 SLE patients of American Indian-European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry-informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs).
RESULTS: The average American Indian genetic ancestry of 2,116 SLE patients was 40.7%. American Indian genetic ancestry conferred increased risks of renal involvement (P < 0.0001, OR 3.50 [95% CI 2.63- 4.63]) and early age at onset (P < 0.0001). American Indian ancestry protected against photosensitivity (P < 0.0001, OR 0.58 [95% CI 0.44-0.76]), oral ulcers (P < 0.0001, OR 0.55 [95% CI 0.42-0.72]), and serositis (P < 0.0001, OR 0.56 [95% CI 0.41-0.75]) after adjustment for age, sex, and age at onset. However, age and sex had stronger effects than genetic ancestry on malar rash, discoid rash, arthritis, and neurologic involvement.
CONCLUSION: In general, American Indian genetic ancestry correlates with lower sociodemographic status and increases the risk of developing renal involvement and SLE at an earlier age.
Authors:
Elena Sánchez; Astrid Rasmussen; Laura Riba; Eduardo Acevedo-Vasquez; Jennifer A Kelly; Carl D Langefeld; Adrianne H Williams; Julie T Ziegler; Mary E Comeau; Miranda C Marion; Ignacio García-De La Torre; Marco A Maradiaga-Ceceña; Mario H Cardiel; Jorge A Esquivel-Valerio; Jacqueline Rodriguez-Amado; José Francisco Moctezuma; Pedro Miranda; Carlos E Perandones; Cecilia Castel; Hugo A Laborde; Paula Alba; Jorge L Musuruana; I Annelise Goecke; Juan-Manuel Anaya; Kenneth M Kaufman; Adam Adler; Stuart B Glenn; Elizabeth E Brown; Graciela S Alarcón; Robert P Kimberly; Jeffrey C Edberg; Luis M Vilá; Lindsey A Criswell; Gary S Gilkeson; Timothy B Niewold; Javier Martín; Timothy J Vyse; Susan A Boackle; Rosalind Ramsey-Goldman; R Hal Scofield; Michelle Petri; Joan T Merrill; John D Reveille; Betty P Tsao; Lorena Orozco; Vicente Baca; Kathy L Moser; Patrick M Gaffney; Judith A James; John B Harley; Teresa Tusié-Luna; Bernardo A Pons-Estel; Chaim O Jacob; Marta E Alarcón-Riquelme
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Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  64     ISSN:  1529-0131     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-31     Completed Date:  2013-01-10     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3687-94     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
European Continental Ancestry Group / genetics*,  statistics & numerical data
Female
Genetic Predisposition to Disease / ethnology
Genotype
Humans
Indians, North American / genetics*,  statistics & numerical data
Indians, South American / genetics*,  statistics & numerical data
Lupus Erythematosus, Systemic / ethnology*,  genetics*
Lupus Nephritis / ethnology,  genetics
Male
Middle Aged
Morbidity
Prevalence
Risk Factors
Socioeconomic Factors
Young Adult
Grant Support
ID/Acronym/Agency:
8 P20-GM-103456-09/GM/NIGMS NIH HHS; AR-43727/AR/NIAMS NIH HHS; K24 AI078004/AI/NIAID NIH HHS; K24-AR-002138/AR/NIAMS NIH HHS; P01 AI083194/AI/NIAID NIH HHS; P01-AI-083194/AI/NIAID NIH HHS; P01-AR-49084/AR/NIAMS NIH HHS; P30-AR-053483/AR/NIAMS NIH HHS; P30-RR-031152/RR/NCRR NIH HHS; P60 2-AR-30692/AR/NIAMS NIH HHS; P60 AR053308/AR/NIAMS NIH HHS; P60-AR-053308/AR/NIAMS NIH HHS; R01 AR057172/AR/NIAMS NIH HHS; R01-AR-052300/AR/NIAMS NIH HHS; R21 AI070304/AI/NIAID NIH HHS; R21-AI-070304/AI/NIAID NIH HHS; RC1 AR058621/AR/NIAMS NIH HHS; UL1 RR024148/RR/NCRR NIH HHS; UL1 TR000154/TR/NCATS NIH HHS; UL1-RR-025005/RR/NCRR NIH HHS; UL1-RR-025741/RR/NCRR NIH HHS
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