Document Detail

Impact of gender on neointimal hyperplasia following coronary artery stenting.
MedLine Citation:
PMID:  17293191     Owner:  NLM     Status:  MEDLINE    
Whether gender affects long-term outcomes after bare metal stent implantation remains controversial. The aim of this study was to examine the impact of gender on neointimal hyperplasia in a large cohort of patients after stent implantation using 3-dimensional intravascular ultrasound. Lumen and stent areas were manually traced at 0.5-mm intervals throughout the stented segment. Using Simpson's method, lumen, stent, and neointimal (stent - lumen) volumes were calculated and standardized by stent length. Women were older, presented more often with hyperlipidemia or hypertension, and had smaller reference vessel diameter and mean stent area, compared with men. Although neointimal hyperplasia and neointimal thickness in women were similar to that in men, the percentage of neointimal hyperplasia (neointimal area divided by stent area) was higher in women due to the smaller stent area. After adjusting for stent area, the percentage of neointimal hyperplasia did not differ by gender. In conclusion, the results of this study indicate that neointimal hyperplasia after bare metal stent implantation in women is similar to that seen in men. Despite the similarity in outcome, there are several gender-specific differences in baseline characteristics.
Hideaki Kaneda; Junya Ako; Toru Kataoka; Takefumi Takahashi; Mitsuyasu Terashima; Katsuhisa Waseda; Akiyoshi Miyazawa; Ali H M Hassan; Yasuhiro Honda; Paul G Yock; Peter J Fitzgerald
Publication Detail:
Type:  Journal Article     Date:  2006-12-21
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  491-3     Citation Subset:  AIM; IM    
Center for Research in Cardiovascular Interventions, Stanford University, Stanford, California, USA.
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MeSH Terms
Coronary Restenosis / pathology*,  ultrasonography
Middle Aged
Retrospective Studies
Sex Factors
Treatment Outcome
Tunica Intima / pathology*,  ultrasonography
Ultrasonography, Interventional

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