Document Detail

Impact of gender in primary prevention of coronary heart disease with statin therapy: a meta-analysis.
MedLine Citation:
PMID:  18793814     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Evidence of lipid-lowering from clinical trials that included women is adequate to support their use in secondary prevention in women with known coronary disease. However the role of statin therapy in primary prevention is still controversial, in particular for female gender. The aim of our study is to perform a meta-analysis comparing by gender the cardiovascular outcomes related to statin therapy in primary prevention. METHODS: We performed a meta-analysis including 8 randomized controlled trials (19,052 and 30,194 men, mean follow-up 3.9 years) that assessed the cardiovascular outcomes related to statin therapy, including studies that provided sex-specific results. MEDLINE and the Cochrane Database, were searched for articles published in English and other languages up to March 2008. RESULTS: Statins do not appear to have a beneficial effect on total mortality for both men and women in primary prevention over the 2.8- to 5.3 year study period (men: 95% Confidence Interval (CI) 0.83-1.04; comparison p = 0.22; women: 0.96; CI 0.81-1.13; p = 0.61). Statin therapy reduced the risk of coronary heart disease (CHD) events in men (0.59; CI 0.48-0.74; p = 0.0001), however in women this risk reduction was weakly significant (0.89 CI 0.79-1.00; p = 0.05) and disappeared when in sensitivity analysis, trials not entirely of primary prevention were excluded (HPS, PROSPER) (0.95 CI 0.78-1.16; comparison p = 0.562). CONCLUSIONS: Our study showed that statin therapy reduced the risk of CHD events in men without prior cardiovascular disease, but not in women. Statins did not reduce the risk of total mortality both in men and women.
Mario Petretta; Pierluigi Costanzo; Pasquale Perrone-Filardi; Massimo Chiariello
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2008-09-14
Journal Detail:
Title:  International journal of cardiology     Volume:  138     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-17     Revised Date:  2010-10-14    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Department of Clinical Medicine, Immunological and Cardiovascular Sciences, Federico II University, Via S. Pansini 5 Naples 80131, Italy.
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MeSH Terms
Coronary Disease / prevention & control*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipidemias / drug therapy*
Sex Characteristics*
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Comment In:
Int J Cardiol. 2010 Sep 24;144(1):145-7   [PMID:  19168241 ]

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