Document Detail

Impact of gender in patients with acute coronary syndrome.
MedLine Citation:
PMID:  19379065     Owner:  NLM     Status:  MEDLINE    
In this article, we review the impact of gender on the pathophysiology, management and outcomes after acute coronary syndrome (ACS). We searched the English-language literature indexed in MEDLINE, Scopus and EBSCOhost Research databases from 1988 through January 2009 using the indexing terms 'gender', 'short- and long-term outcomes' and 'acute coronary syndrome' and 'myocardial infarction'. Data comparing gender differences in outcomes after ACS showed that females have a higher mortality rate than males. Observational studies showed that guideline-recommended management strategies are used significantly less frequently in females than males. The undertreatment and worse outcome of female patients with ACS are probably multifactorial and have been reported in different ethnicities and cultures. However, there are conflicting data regarding to the impact of gender on early versus long-term outcomes, the benefit of early intervention in low- and high-risk females and the influence of unmeasured selection biases in the use of therapies in the observational data. These gender discrepancy trends warrant close follow-up, as this might reflect changes in primary and secondary prevention in the community. Furthermore, gender discrepancy gives an indication of healthcare quality and whether care is given in an unbiased manner. All high-risk females, and males with ACS, should receive optimal medical management, coronary angiography and revascularization whenever indicated.
Ayman A El-Menyar; Jassim Al Suwaidi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  7     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  411-21     Citation Subset:  IM    
Weill Cornell Medical School and HMC, Hamad General Hospital, Cardiology Department, PO Box 3050, Doha, Qatar.
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MeSH Terms
Acute Coronary Syndrome / mortality,  physiopathology,  therapy*
Healthcare Disparities / statistics & numerical data*
Practice Guidelines as Topic
Quality of Health Care / statistics & numerical data*
Selection Bias
Sex Factors
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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