| Impact of gamma-chain cytokines on T cell homeostasis in HIV-1 infection: therapeutic implications. | |
| | |
MedLine Citation:
|
PMID: 20433577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CD4(+) T cell lymphocytes are a major target for human immunodeficiency virus type-1 (HIV-1) infection. During this chronic infection, CD4(+) T cell loss (induced through direct viral replication), generalized immune activation and increased susceptibility to apoptosis result in impaired T cell homeostasis with subsequent development of opportunistic infections and cancers. Highly active antiretroviral therapy (HAART) has a well-defined, beneficial effect on HIV-1-related clinical outcome; however, it does not lead to normalization of immune dysregulation. In order to boost both CD4(+) T cell restoration and HIV-1 specific immunity, immunotherapy with gamma-chain cytokines has been used in HIV-1-infected patients during concomitant HAART. In this review, we summarize the role of gamma-chain cytokines, especially interleukin (IL)-2 and IL-7, in influencing T cell homeostasis and proliferation, and discuss how immunotherapy with these cytokines may be beneficial to reconstitute the T cell compartment in the context of HIV-1 infection. The intriguing results of two large trials evaluating the efficacy of IL-2 in restoring immune function during HIV-1 infection are also discussed. In addition, we consider the promises and caveats of the first phase I/II clinical trials with IL-7 in HIV-1-infected patients and the knowledge that is still lacking in the field of T cell reconstitution through gamma-chain cytokines. |
| | |
Authors:
|
M-L Gougeon; F Chiodi |
Related Documents
:
|
11312017 - Plasmid dna encoding caprine interferon gamma inhibits antibody response to caprine art... 2784507 - Stimulation of the human immunodeficiency virus type 1 enhancer by the human t-cell leu... 15053337 - B lymphocyte dysfunctions in hiv infection. 10640747 - Neuronal fractalkine expression in hiv-1 encephalitis: roles for macrophage recruitment... 18505397 - Protective and destructive innate immune responses to enteropathogenic escherichia coli... 20919637 - Bh3-only proteins and their effects on cancer. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of internal medicine Volume: 267 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-03 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
|
Languages: eng Pagination: 502-14 Citation Subset: IM |
Affiliation:
|
Institut Pasteur, Paris, France. mlgougeo@pasteur.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Retroviral Agents
/
pharmacology* Apoptosis / drug effects CD4-Positive T-Lymphocytes* / drug effects, immunology Cell Proliferation / drug effects Chronic Disease HIV Infections* / drug therapy, immunology HIV-1* Homeostasis / drug effects Humans Interleukin-2 / pharmacology* Interleukin-7 / pharmacology* Receptors, Cytokine / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Retroviral Agents; 0/Interleukin-2; 0/Interleukin-7; 0/Receptors, Cytokine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything.
Next Document: Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism.