Document Detail


Impact of formulation excipients on human intestinal transit.
MedLine Citation:
PMID:  16734983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The accelerating effect of polyethylene glycol 400 on small intestinal transit has been previously reported. The aim of this study was to investigate the influence of other solubility-enhancing excipient, propylene glycol, D-alpha-tocopheryl-polyethylene glycol-1,000 succinate (VitE-TPGS) and Capmul MCM, on human intestinal transit. A 5-g dose of each excipient was administered to seven healthy male subjects. Propylene glycol and VitE-TPGS were administered dissolved in 150 mL water. Capmul MCM was administered in the form of four 000 hard gelatin capsules to mask its taste and then given with 150 mL water. On a separate occasion, 150 mL water was administered as the control. Each formulation was radiolabelled with technetium-99 m to follow its transit using a gamma camera. The mean small intestinal transit times were 234, 207, 241 and 209 min for the control, propylene glycol, VitE-TPGS and Capmul MCM treatments, respectively. Although there were differences in the small intestinal transit times for the excipients investigated compared with the control, none of the results were statistically significant. Unlike polyethylene glycol 400 at the same dose of 5 g, the excipients tested (propylene glycol, VitE-TPGS and Capmul MCM) had little or no impact on small intestinal transit.
Authors:
Julia D R Schulze; Diane A I Ashiru; Mandeep K Khela; David F Evans; Rajesh Patel; Gary E Parsons; Mark D Coffin; Abdul W Basit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  58     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-31     Completed Date:  2006-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  821-5     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemistry, Pharmaceutical
Excipients / pharmacology*
Gastric Emptying / drug effects
Gastrointestinal Transit / drug effects*
Glycerides / pharmacology*
Humans
Male
Middle Aged
Octanoic Acids
Polyethylene Glycols / pharmacology
Propylene Glycol / pharmacology*
Vitamin E / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Excipients; 0/Glycerides; 0/Octanoic Acids; 0/Polyethylene Glycols; 1406-18-4/Vitamin E; 26402-26-6/monooctanoin; 57-55-6/Propylene Glycol; 9002-96-4/alpha-tocopheryl polyethylene glycol succinate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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