Document Detail

Impact of food intake on the pharmacokinetics of first-line antituberculosis drugs in Taiwanese tuberculosis patients.
MedLine Citation:
PMID:  24594059     Owner:  NLM     Status:  Publisher    
BACKGROUND/PURPOSE: Under the directly observed treatment, short course (DOTS) program, antituberculosis (anti-TB) medications were possibly taken at random time, regardless of whether it was prior to or after meals. This study was to evaluate the impact of food intake on pharmacokinetic profiles of first-line TB drugs in Taiwanese TB patients, as well as the relationship between drug levels and pharmacogenetics.
METHODS: This open-label, randomized, cross-over study included newly diagnosed Taiwanese TB patients treated between January 2010 and February 2011 at Taipei Medical University-Wan Fang Hospital. Rifater [a fixed-dose combination formulation of isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA)] and ethambutol (EMB) were given according to national TB guidelines. Blood samples were collected prior to and 1 hour, 2 hours, 4 hours, 6 hours, and 10 hours after dosing under fasting or postprandial conditions. Pharmacokinetic parameters of the maximum serum concentration (Cmax), time to Cmax, and area under the serum concentration-time curve from the beginning to the 10(th) hour (AUC0-10) were calculated.
RESULTS: Sixteen TB patients were included and received anti-TB treatment under the DOTS program after discharge. The overall effects showed that food intake reduced the mean Cmax (INH: 40.6%, RIF: 40.2%, EMB 34.4%, PZA: 24.4%) and AUC0-10 (INH: 21.3%, RIF: 26.4%, EMB: 12.2%, PZA: 12.0%). Meanwhile, food increased the time to Cmax (INH: 78.1%, RIF: 151.3%, EMB: 41.4%, PZA: 148.9%).
CONCLUSION: Significantly lower serum drug concentrations were observed under postprandial conditions than fasting conditions for INH, RIF, and PZA. The impact of taking random anti-TB drugs under the DOTS program instead of taking drugs regularly prior to meals requires further study.
Hsien-Chun Lin; Ming-Chih Yu; Hsing-Jin Liu; Kuan-Jen Bai
Related Documents :
8627509 - Behavioral basis of second intermediate host specificity among four species of haematol...
21180989 - Assessing food dietary intakes in japanese-brazilians using factor analysis.
21495899 - The effects of consuming eggs for lunch on satiety and subsequent food intake.
21249159 - Polyamines in foods: development of a food database.
7722629 - Development of memory and the hippocampus: comparison of food-storing and nonstoring bi...
22170019 - Heat makes a difference in activity-based anorexia: a translational approach to treatme...
22607739 - Gender and race are significant determinants of students' food choices on a college cam...
12798779 - History of food acceptance research in the us army.
24587259 - Road salts as environmental constraints in urban pond food webs.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-1
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  -     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  STRAD pseudokinases regulate axogenesis and LKB1 stability.
Next Document:  Liquid crystalline epoxy nanocomposite material for dental application.