| Impact of fibroblast growth factor 23 on lipids and atherosclerosis in hemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 20609185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Levels of fibroblast growth factor (FGF) 23, a phosphatonin, are frequently elevated in patients with end-stage renal disease (ESRD) who are on maintenance hemodialysis (MHD). However, the role of FGF23 remains unclear because renal FGF receptor function might be impaired. The present cross-sectional study examines a cohort of patients (n = 196) on MHD who were not undergoing therapy with lipid-lowering drugs including sevelamer. Non-fasting venous blood samples were withdrawn before the hemodialysis (HD) session on the third day after the previous HD session to measure serum levels of albumin, calcium (Ca), phosphate (P), alkaline phosphatase, intact parathyroid hormone (PTH), total cholesterol (C), high-density lipoprotein (HDL)-C, low-density lipoprotein(LDL)-C, oxidative LDL-C, high-sensitivity C-reactive protein (HsCRP), interleukin-6 (IL-6), and FGF23. Nutritional status was assessed using the geriatric nutritional risk index (GNRI). Carotid intima-medial thickness (CIMT) was assessed using a B-mode ultrasound scanner. FGF23 was positively correlated with P, Ca(alb)xP product, and intact PTH, and inversely correlated with C and non-HDL-C. In the higher FGF23 tertile, levels of both non-HDL-C and C were significantly decreased and CIMT was less elevated compared to the lower FGF23 tertile. Multivariate analysis showed that the higher FGF23 tertile was independently associated with decreases in C (adjusted r(2) = 0.14) and non-HDL-C (adjusted r(2) = 0.20) levels and with a less-pronounced increase in CIMT (adjusted r(2) = 0.14). High FGF23 appears to be an independent biomarker of a decrease in C and non-HDL-C that is negatively associated with atherosclerosis in patients on MHD. |
| | |
Authors:
|
Eijin Ashikaga; Hirokazu Honda; Hiroki Suzuki; Nozomu Hosaka; Yuki Hirai; Daisuke Sanada; Mari Nakamura; Hisako Nagai; Kei Matsumoto; Noriyuki Kato; Masanori Mukai; Makoto Watanabe; Keiko Takahashi; Kanji Shishido; Tadao Akizawa |
Related Documents
:
|
20807165 - Metabolic syndrome in adolescents with polycystic ovary syndrome. 1517695 - Lipoproteins and apolipoproteins in human pleural effusions. 12672915 - Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit diffe... 12074175 - Influence of fish consumption on the distribution of serum cholesterol in lipoprotein f... 1894545 - Productivity and profitability of twin births in beef cattle. 16672205 - Differences in nutrient intakes and physical activity levels of japanese and australian... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 14 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-07-08 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
|
Languages: eng Pagination: 315-22 Citation Subset: IM |
Affiliation:
|
Division of Nephrology, Department of Medicine, Showa University, Hatanodai Shinagawa-ku, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Atherosclerosis / etiology, physiopathology* Biological Markers / blood Cross-Sectional Studies Female Fibroblast Growth Factors / blood* Humans Kidney Failure, Chronic / physiopathology, therapy* Lipids / blood Male Middle Aged Multivariate Analysis Prospective Studies Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Lipids; 0/fibroblast growth factor 23; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: How does short-term low-dose simvastatin influence serum prohepcidin levels in patients with end-sta...
Next Document: Ultrasonographic detection of thyroid nodules in hemodialysis patients in Japan.