Document Detail


Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters.
MedLine Citation:
PMID:  21327969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine how the timing of hypoxic exposure results in specific childhood outcomes and whether there is a differential effect by sex.
METHODS: A sample of 10,879 prospectively followed pregnancies was drawn from the Boston and Providence sites (New England, NE) of the National Collaborative Perinatal Project. Based on placental pathology, we developed and validated a measure of probable chronic placental hypoxia (CHP) and contrasted the effects of acute perinatal hypoxia on age 7 emotional, behavioral, and cognitive outcomes.
RESULTS: Perinatal hypoxia had a significant impact on multiple behavioral and cognitive outcomes in boys and girls by age 7, in contrast to probable CHP which had a differential effect on girls and boys such that there was decreased verbal IQ and increased inhibition in females alone.
CONCLUSIONS: Findings underscore the importance of considering the timing of obstetric complications and offspring sex in investigations of the impact of fetal and perinatal hypoxia on offspring's outcomes throughout the life course.
Authors:
Michael Anastario; Carolyn M Salafia; Garrett Fitzmaurice; Jill M Goldstein
Related Documents :
21265999 - Maternal obesity and labour complications following induction of labour in prolonged pr...
15530549 - Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staini...
1173979 - Identification and quantitative determination of steroids in bovine corpus luteum durin...
19747959 - Progesterone regulation of primordial follicle assembly in bovine fetal ovaries.
24552449 - A pilot study to determine whether progestogen supplementation using dydrogesterone dur...
21413599 - Comparison of perinatal and obstetrics outcomes among early adolescents, late adolescen...
9876709 - Laparoscopic appendectomy and cholecystectomy during pregnancy: six case reports.
18802489 - Tracing the molecular pathogenesis of antiphospholipid syndrome.
1445139 - Pregnancy following infertility.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-17
Journal Detail:
Title:  Social psychiatry and psychiatric epidemiology     Volume:  47     ISSN:  1433-9285     ISO Abbreviation:  Soc Psychiatry Psychiatr Epidemiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-21     Completed Date:  2012-06-26     Revised Date:  2013-07-24    
Medline Journal Info:
Nlm Unique ID:  8804358     Medline TA:  Soc Psychiatry Psychiatr Epidemiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  455-64     Citation Subset:  IM    
Affiliation:
Division of Women's Health, Department of Medicine, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital (BWH), One Brigham Circle, 1620 Tremont Street, Boston, MA 02120, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Boston
Child
Cognition Disorders / etiology*
Female
Fetal Hypoxia / complications*
Humans
Male
Outcome Assessment (Health Care)
Perinatal Care*
Pregnancy
Pregnancy Complications / psychology*
Prospective Studies
Rhode Island
Sex Factors
Grant Support
ID/Acronym/Agency:
P50 MH082679/MH/NIMH NIH HHS; P50 MH082679/MH/NIMH NIH HHS; R01 MH056956/MH/NIMH NIH HHS; R01 MH56956/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phase II-Inducing, Polyphenols Content and Antioxidant Capacity of Corn (Zea mays L.) from Phenotype...
Next Document:  Genotoxicity and carcinogenicity studies of antihistamines.