Document Detail

Impact of female hormones on blood pressure: review of potential mechanisms and clinical studies.
MedLine Citation:
PMID:  14594572     Owner:  NLM     Status:  MEDLINE    
In recent studies, it has been found that postmenopausal hormonal therapy is associated with an increased incidence of cardiovascular disease. Experimental studies suggest several potential mechanisms by which estrogens might decrease blood pressures, and estrogen administration attenuates hypertension in several animal models. In humans, although oral contraceptive agents are frequently associated with increases in blood pressure, blood pressure was not increased or was minimally increased in prospective clinical trials of hormone therapy in postmenopausal women. These observations suggest that the excess rates of cardiovascular disease are not caused by increased blood pressure.
Jane Morley Kotchen; Theodore A Kotchen
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  5     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-03     Completed Date:  2004-09-30     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-12     Citation Subset:  IM    
Division of Epidemiology, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
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MeSH Terms
Blood Pressure / drug effects*
Cardiovascular Diseases / chemically induced,  epidemiology,  physiopathology
Contraceptive Agents, Female / pharmacology
Endothelium, Vascular / drug effects,  physiopathology
Estrogen Replacement Therapy
Estrogens / pharmacology
Hormones / pharmacology*
Muscle, Smooth, Vascular / drug effects,  physiopathology
Progesterone / pharmacology
Risk Assessment
Vascular Resistance / drug effects
Reg. No./Substance:
0/Contraceptive Agents, Female; 0/Estrogens; 0/Hormones; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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