Document Detail


Impact of feeding and post prandial time on plasma ketone bodies in sows during transition and lactation.
MedLine Citation:
PMID:  23148246     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Two experiments were conducted with the aim of studying how dietary fat source, reproductive stage (Exp. 1), and diurnal variation (Exp. 2) affect plasma ketone bodies in sows. In Exp. 1, 40 second-parity sows were fed 1 of 5 lactation diets from 7 d pre-partum until 28 d postpartum with low or high levels (3 or 8%) of dietary fats with different proportions of medium and long chain fatty acids. Blood was obtained by jugular venipuncture on d 3 and 7 pre-partum and on d 1, 10, 17, and 28 post-partum, and concentrations of plasma beta-hydroxy butyric acid (BHBA), acetoacetate + acetone (AcAc+Ac), glucose, NEFA, lactate, acetate, and butyrate were determined. For 4 out of the 5 treatments, plasma BHBA decreased slightly, while plasma AcAc+Ac remained stable. However, plasma BHBA (P < 0.01) and AcAc+Ac (P < 0.001) doubled after d 10 of lactation in sows fed 4% octanoic acid and 4% fish oil diet (4+4% FO; P < 0.001) compared with earlier in lactation (P < 0.001). Plasma AcAc+Ac was positively related to BHBA (P < 0.01), glucose (P < 0.05), and butyrate (P < 0.001), and negatively related to the acetate to butyrate ratio (P < 0.001). In addition, plasma BHBA was positively related to lactate (P < 0.01), acetate, and butyrate (P < 0.05). In Exp. 2, diurnal variations of plasma metabolites were studied in 5 sows sampled every second hour from a jugular catheter throughout a 24-h period on d 5 and 17 of lactation and analyzed as in Exp. 1. In addition, milk and urine samples were collected and analyzed for BHBA and AcAc+Ac. No diurnal variations in plasma BHBA or AcAc+Ac were observed and plasma AcAc+Ac was unchanged from d 5 to 17 of lactation (3.7 μM), whereas BHBA dropped from 58 μM on d 5 of lactation to 52 μM on d 17 of lactation (P < 0.05). Minor amounts of AcAc+Ac were found in urine (8.6 μM) and this was not affected by days in milk, whereas the content of AcAc+Ac in milk and BHBA in milk and urine were below the detection limit in 4 of 5 sows. In conclusion, dietary fat source affected the plasma levels of ketone bodies but the concentrations were much lower than normally observed in dairy cows and, therefore, primary ketosis does not appear to be a major problem in sows. In addition, this study indicates that the intermediary metabolism of sows was challenged when sows were exposed to high fat diets in late gestation.
Authors:
P K Theil; A K Olesen; C Flummer; G Sørensen; N B Kristensen
Related Documents :
17874826 - Enhancement effects of vitamin k1 (phylloquinone) or vitamin k2 (menaquinone-4) on inte...
23219116 - Effect of physical form of forage on performance, feeding behavior, and digestibility o...
11516636 - Enteral infusion of phosphatidylcholine increases the lymphatic absorption of fat, but ...
23163916 - Effects of antimicrobials fed as dietary growth promoters on fecal shedding of campylob...
17209086 - Unusual case of osteopenia associated with nutritional calcium and vitamin d deficiency...
17874826 - Enhancement effects of vitamin k1 (phylloquinone) or vitamin k2 (menaquinone-4) on inte...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Animal Science, Faculty of Science and Technology, Aarhus University, DK-8830 Tjele, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Forage and co-product systems for stockers in the South: have fundamental shifts in markets changed ...
Next Document:  Effect of dietary copper and breed on gene products involved in copper acquisition, distribution, an...