Document Detail


Impact of fasting and postprandial state on plasma carnitine concentrations during aerobic exercise in type 2 diabetes.
MedLine Citation:
PMID:  17721749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of metabolic states of fasting and post-absorption on plasma concentrations of free carnitine (FC), acylcarnitine (AC) and total carnitine (TC) were compared during submaximal exercise in subjects with type 2 diabetes mellitus. Ten sedentary men (54+/-5 years) treated with oral hypoglycaemic agents were tested on two separate occasions: following an overnight fast and 2 h after a 395-kcal standardised breakfast. Exercise was performed at 60% of [Formula: see text]O(2peak) on a cycle ergometer for 60 min. Blood samples were drawn at rest for baseline values and following 60 min of exercise and 30 min of recovery. Our results show that: (1) baseline levels of TC, FC and AC were similar in fasted and postprandial groups, (2) TC and AC levels were increased during exercise in the fasted group only, (3) FC levels were decreased during exercise in both fasted and postprandial state and (4) the AC/FC ratio increased during exercise in the fasted group. Our results indicate that the metabolic state of the diabetic patient is associated with a different plasma carnitine status. These patterns may reflect differences in energy metabolism associated with fasting and postprandial hyperglycaemia.
Authors:
A Ferland; T L Broderick; A Nadeau; S Simard; J Martin; P Poirier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-26
Journal Detail:
Title:  Acta diabetologica     Volume:  44     ISSN:  0940-5429     ISO Abbreviation:  Acta Diabetol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  114-20     Citation Subset:  IM    
Affiliation:
University Institute of Cardiology and Pneumology, Laval Hospital, Laval University, 2725 Chemin Sainte-Foy, Sainte-Foy, Québec, Canada, G1V 4G5.
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MeSH Terms
Descriptor/Qualifier:
Aerobiosis
Body Mass Index
Carnitine / blood*
Diabetes Mellitus, Type 2 / blood*,  drug therapy,  physiopathology
Exercise / physiology*
Fasting / physiology*
Fatty Acids, Nonesterified / blood
Hemoglobin A, Glycosylated / analysis
Humans
Hypoglycemic Agents / therapeutic use
Insulin / blood
Male
Oxygen Consumption*
Postprandial Period*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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