| Impact of an extensive in situ component on the presence of residual disease in screen detected breast cancer. | |
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MedLine Citation:
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PMID: 1744869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigates the histopathological characteristics of a consecutive series of 100 screen detected breast cancers in relation to residual disease. Tumour type, size, grade, resection margins and extent of primary or associated in situ disease were all assessed by one pathologist. Thirty-seven women underwent further surgery (wider excision or mastectomy) and the resected specimen was examined for residual in situ or invasive cancer. In total, 36 cancers had an extensive in situ component, of which 69% were predominantly intraduct carcinoma of comedo type. Of the 37 women who underwent further resection, 21 (57%) women had residual cancer. Of those with initial disease at the resection margin, 16/25 (64%) had residual disease. Five of 12 (42%) with disease close to (within 2-3 mm) but not at the margin had residual disease. Of those with an extensive in situ component, 18/25 (72%) had residual disease, whereas only 2/12 (17%) women with none or some in situ disease had residual cancer. In screen detected breast cancer, residual cancer was present in 72% of women with an extensive in situ component at initial surgery. These women comprise a group in which conservation surgery may be inappropriate if completeness of excision is considered a prerequisite for breast conserving surgery. |
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Authors:
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I D Campbell; J M Theaker; G T Royle; R Coddington; R Carpenter; A Herbert; I Moore; C Rubin; I Taylor; P B Guyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Royal Society of Medicine Volume: 84 ISSN: 0141-0768 ISO Abbreviation: J R Soc Med Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-01-15 Completed Date: 1992-01-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802879 Medline TA: J R Soc Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 652-6 Citation Subset: IM |
Affiliation:
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University Surgical Unit, Southampton General Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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pathology*,
prevention & control,
surgery Carcinoma in Situ / pathology* Female Humans Mass Screening Mastectomy Reoperation |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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