Document Detail

Impact of experimental diabetes on the maternal uterine vascular remodeling during rat pregnancy.
MedLine Citation:
PMID:  22383782     Owner:  NLM     Status:  MEDLINE    
Normal pregnancy is associated with an increase in uteroplacental blood flow in part due to growth and remodeling of the maternal uterine vasculature. In this study, we characterized the effect of diabetic pregnancy on vascular growth of the maternal uterine vasculature and on the passive mechanical properties of the uterine resistance arteries. Diabetes was induced in pregnant rats by injection of streptozotocin and confirmed by development of hyperglycemia. Fetuses of diabetic rats were significantly smaller and placentas larger compared to controls. Pregnancy-induced axial elongation of the mesometrial uterine vasculature was not altered by diabetes. Vascular wall thickness was unchanged between groups. Wall distensibility was increased and the rate constant of an exponential function fitted to stress-strain curve was significantly reduced demonstrating decreased wall stiffness in diabetic uterine radial arteries compared to controls. We conclude that experimental diabetes in rat pregnancy does not compromise the growth of maternal uterine vasculature but alters passive mechanical properties of the uterine radial arteries.
Julie K Phillips; Amanda M Vance; Renju S Raj; Maurizio Mandalà; Erika A Linder; Natalia I Gokina
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  19     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-06-27     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-31     Citation Subset:  IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, Vermont, USA.
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MeSH Terms
Diabetic Angiopathies / pathology*,  physiopathology
Disease Models, Animal
Pregnancy in Diabetics / pathology*,  physiopathology
Rats, Sprague-Dawley
Uterine Artery / pathology,  physiopathology
Uterus / blood supply*,  pathology*,  physiopathology
Vascular Resistance
Vascular Stiffness
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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