| Impact of exercise training on oxidative stress in individuals with a spinal cord injury. | |
| | |
MedLine Citation:
|
PMID: 20364349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Individuals with a spinal cord injury (SCI) have an increased cardiovascular risk. We hypothesize that (anti)oxidative imbalance is associated with the increased cardiovascular risk in SCI, while exercise can reverse this status. The aim of the study is to compare baseline levels of oxidative stress and antioxidative capacity between individuals with SCI and able-bodied (AB) subjects, and to assess acute and long-term effects of functional electrical stimulation (FES) exercise on oxidative stress and antioxidative capacity in SCI. Venous blood was taken from subjects with an SCI (n = 9) and age- and gender-matched AB subjects (n = 9) to examine oxidative stress through malondialdehyde (MDA) levels, while superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme levels represented anti-oxidative capacity. Subsequently, subjects with an SCI performed an 8-week FES exercise training period. Blood was taken before and after the first exercise bout and after the last FES session to examine the acute and chronic effect of FES exercise, respectively. Baseline levels of MDA, SOD and GPx were not different between individuals with SCI and AB subjects. SCI demonstrated a correlation between initial fitness level and MDA (R = -0.83, P = 0.05). MDA, SOD and GPx levels were neither altered by a single FES exercise bout nor by 8 weeks FES training. In conclusion, although individuals with an SCI demonstrate a preserved (anti)oxidative status, the correlation between fitness level and (anti)oxidative balance suggests that higher fitness levels are related to improved (anti)oxidative status in SCI. Nonetheless, the FES exercise stimulus was insufficient to acutely or chronically change (anti)oxidative status in individuals with an SCI. |
| | |
Authors:
|
Noortje van Duijnhoven; Evelyne Hesse; Thomas Janssen; Will Wodzig; Peter Scheffer; Maria Hopman |
Related Documents
:
|
12519649 - Olfactory function after mild traumatic brain injury. 15458729 - The "best" tidal volume for managing acute lung injury/acute respiratory distress syndr... 20463499 - Core stability and bicycling. 19519909 - The relationship between lower extremity alignment and medial tibial stress syndrome am... 18317179 - Resistive simulated weightbearing exercise with whole body vibration reduces lumbar spi... 687049 - Inverted spinal traction. 22348439 - A comparison of the changes in cardiac output and systemic vascular resistance during e... 12135449 - Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation ... 11687509 - Transcriptional activation of the il-6 gene in human contracting skeletal muscle: influ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-03 |
Journal Detail:
|
Title: European journal of applied physiology Volume: 109 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-11-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1059-66 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Noord 21, 6525 EZ, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antioxidants / metabolism* Exercise Therapy / methods* Humans Male Oxidative Stress* Physical Exertion* Physical Fitness* Reactive Oxygen Species / metabolism* Spinal Cord Injuries / physiopathology*, rehabilitation* |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Reactive Oxygen Species |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterogeneity of muscle deoxygenation kinetics during two bouts of repeated heavy exercises.
Next Document: Quantitative analysis of directional strengths in jointly stationary linear multivariate processes.