Document Detail


Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model.
MedLine Citation:
PMID:  19218333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: In late-stage chronic heart failure (CHF), elevated cytokines and cachexia are often observed. Several studies have shown that exercise training exerts beneficial effects on skeletal muscle in this setting. Furthermore, it has been shown that the expression of myostatin, a key regulator of skeletal muscle mass, is increased in a variety of cachectic states. This study aimed to investigate the expression of myostatin in CHF, the influence of exercise training on myostatin levels, and regulation of myostatin by tumour necrosis factor-alpha (TNF-alpha).
METHODS AND RESULTS: In an animal model of CHF (LAD-ligation model), protein expression of myostatin was elevated 2.4-fold in the skeletal muscle and more than four-times in the myocardium, compared with control (Co). Exercise training on a treadmill over 4 weeks led to a significant reduction in myostatin protein expression in the skeletal muscle and the myocardium of CHF animals, with values returning to baseline levels. In differentiated C2C12 cells, TNF-alpha induced the expression of myostatin through a p38MAPK-dependent pathway involving nuclear factor kappa-B (NF-kappaB). The increased TNF-alpha mRNA levels in the skeletal muscle of CHF animals correlated significantly with myostatin expression.
CONCLUSION: These alterations in myostatin expression in the skeletal and heart muscle following exercise training could help to explain the beneficial anti-catabolic effects of exercise training in CHF.
Authors:
Karsten Lenk; Robert Schur; Axel Linke; Sandra Erbs; Yasuharu Matsumoto; Volker Adams; Gerhard Schuler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-13
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-06-30     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  342-8     Citation Subset:  IM    
Affiliation:
Clinic of Cardiology, University Leipzig-Heart Center Leipzig, Strümpellstrasse 39, D-04289 Leipzig, Germany. karsten.lenk@med.uni-leipzig.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Disease Models, Animal
Electrophoresis, Polyacrylamide Gel
Exercise Therapy / methods*
Gene Expression*
Heart Failure / genetics,  metabolism,  rehabilitation*
Muscle, Skeletal / metabolism*,  pathology
Myocardium / metabolism*,  pathology
Myostatin / biosynthesis,  genetics*
RNA / genetics*
Rats
Rats, Inbred WKY
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factor-alpha / biosynthesis,  genetics
Chemical
Reg. No./Substance:
0/Myostatin; 0/Tumor Necrosis Factor-alpha; 63231-63-0/RNA

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