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Impact of exercise on pro inflammatory cytokine levels and epigenetic modulations of tumor-competitive lymphocytes in Non-Hodgkin-Lymphoma patients-Randomised controlled trial.
MedLine Citation:
PMID:  24913351     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Physical activity is associated with decreased cancer (recurrence) risk and a reduction of treatment specific side effects. Exercise modulates cytokine-expression and shows beneficial effects on cancer patients` immune system. We investigated (i) if Non-Hodgkin-Lymphoma patients have elevated serum macrophage migration inhibiting factor (MIF) and Interleukin-6 (IL-6) levels after immunochemotherapy, (ii) if physical activity influences cytokine serum levels and (iii) if serum cytokine levels are associated with histone modifications in tumor-competitive immune cells.
METHODS: 30 patients and 10 healthy controls were randomised into an intervention and a control group. Participants of the intervention group exercised once for 30 minutes at moderate intensity on a bicycle ergometer. Blood samples were collected twice, before and after the intervention. MIF and IL-6 serum concentrations were detected by ELISA. Natural killer cells and CD8(+) T-lymphocytes were isolated by magnetic labeled cell sorting. Isolated cells were stained and analyzed for global histone acetylation at histone 4, lysine 5 and histone three, lysine 9.
RESULTS: Patients showed higher serum MIF and IL-6 baseline levels, and reduced NK-cell histone acetylation, indicating a reduced transcriptional activity of tumor competitive lymphocytes. Changes in MIF correlated with altered NK-cell histone acetylation, leading to the hypothesis that MIF impacts NK-cells via epigenetic modifications. Further, the exercise intervention was associated with an increase in IL-6 and CD8(+) T-lymphocyte histone acetylation.
CONCLUSIONS: We conclude that exercise induces changes in cytokine levels, thereby possibly affecting epigenetic patterns and activity of tumor competitive lymphocytes. This article is protected by copyright. All rights reserved.
P Zimmer; F T Baumann; W Bloch; A Schenk; C Koliamitra; P Jensen; A Mierau; T Hülsdünker; N Reinart; M Hallek; T Elter
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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