Document Detail


Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease.
MedLine Citation:
PMID:  22040668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The etiology of neurodegenerative disorders like Parkinson's disease remains unknown, although many genetic and environmental factors are suggested as likely causes. Neuronal oxidative stress and mitochondrial dysfunction have been implicated as possible triggers for the onset and progression of Parkinson's neurodegeneration. We have recently shown that long-term treadmill exercise prevented neurological, mitochondrial and locomotor deficits in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-induced mouse model of Parkinson's disease that was originally established in our laboratory. In the present study, we further demonstrated that long-term exercise attenuated both cytochrome c release and elevated levels of p53, which are known to be associated with mitochondrial dysfunction in the striatum of this chronic model. On the other hand, the expressions of mitochondrial transcription factor A and peroxisome proliferator-activated receptor gamma coactivator 1α were unexpectedly upregulated in the striatum of this chronic model, but long-term exercise training brought their levels down closer to normal. Our findings suggest that maintaining normal mitochondrial function is essential for preventing the process of Parkinson's disease-like neurodegeneration, whereas stimulating the mitochondrial transcription factors for biogenesis is not obligatory.
Authors:
Gaurav Patki; Yuen-Sum Lau
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-21
Journal Detail:
Title:  Neuroscience letters     Volume:  505     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-03-22     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  268-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Pharmaceutic / toxicity
Analysis of Variance
Animals
Chronic Disease
Corpus Striatum / metabolism*,  pathology
Cytochromes c / metabolism
DNA-Binding Proteins / genetics,  metabolism
Disease Models, Animal
Exercise Test
High Mobility Group Proteins / genetics,  metabolism
MPTP Poisoning / chemically induced,  pathology*,  rehabilitation*
Male
Mice
Mice, Inbred C57BL
Physical Conditioning, Animal / methods*
Probenecid / toxicity
RNA, Messenger / metabolism
Trans-Activators / genetics,  metabolism
Transcription Factors / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
NS 47920/NS/NINDS NIH HHS; R01 NS047920/NS/NINDS NIH HHS; R01 NS047920-05/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Pharmaceutic; 0/DNA-Binding Proteins; 0/High Mobility Group Proteins; 0/Ppargc1a protein, mouse; 0/RNA, Messenger; 0/Tfam protein, mouse; 0/Trans-Activators; 0/Transcription Factors; 9007-43-6/Cytochromes c; PO572Z7917/Probenecid
Comments/Corrections

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