| Impact of erythropoiesis-stimulating agents on morbidity and mortality in patients with heart failure: an updated, post-TREAT meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 20525985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Randomized clinical trials have suggested that treatment of anaemia with erythropoiesis-stimulating agents (ESAs) in patients with cancer or chronic kidney disease may increase cardiovascular risk. We therefore examined the effect of treating anaemia with an ESA in patients with heart failure in a meta-analysis of randomized clinical trials, including the recently reported TREAT study. METHODS AND RESULTS: We performed a systematic review and meta-analysis of all prospective, randomized, controlled studies of ESAs enrolling patients with heart failure and reporting data on mortality or non-fatal heart failure events. Of 10 trials initially identified by our search strategy, we pooled data from 9 placebo-controlled studies enrolling a total of 2039 patients, of whom 1023 (50.2%) were allocated to ESA treatment. The pooled risk ratio for ESA treatment relative to placebo was 1.03 [95% confidence interval (CI): 0.89-1.21, P = 0.68] for overall mortality and 0.95 (95% CI: 0.82-1.10, P = 0.46) for worsening heart failure. CONCLUSIONS: The use of ESAs to manage anaemia in patients with heart failure was associated with a neutral effect on both mortality and non-fatal heart failure events. Definitive assessment of the balance of risk and benefit in this population awaits the completion of a randomized clinical trial adequately powered to assess clinical outcomes. |
| | |
Authors:
|
Akshay Desai; Eldrin Lewis; Scott Solomon; John J V McMurray; Marc Pfeffer |
Related Documents
:
|
16195625 - Valsartan decreases type i collagen synthesis in patients with hypertrophic cardiomyopa... 12549975 - Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with ... 17661735 - Nebivolol: third-generation beta-blockade. 15230495 - Age and quality of in-hospital care of patients with heart failure. 8027495 - Mite allergen control with acaricide fails. 10861155 - Effect of intravenous versus epidural fentanyl on the minimum local analgesic concentra... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review Date: 2010-06-05 |
Journal Detail:
|
Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-23 Completed Date: 2011-01-11 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 936-42 Citation Subset: IM |
Affiliation:
|
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. adesai@partners.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia
/
complications,
drug therapy* Heart Failure / complications, epidemiology* Hematinics / therapeutic use* Humans Morbidity / trends Prognosis Survival Rate / trends |
| Chemical | |
Reg. No./Substance:
|
0/Hematinics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of left ventricular function with magnetic resonance imaging vs. echocardiography, contra...
Next Document: Galectin-3, cardiac structure and function, and long-term mortality in patients with acutely decompe...