Document Detail


Impact of endotoxin exposure after exhausting exercise on the immune system in solid organ transplant recipients.
MedLine Citation:
PMID:  22876728     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Subsequent to prolonged exhausting exercise a transient immunosuppression is often observed in athletes. This so-called "open window" results in a reduced resistance of the athletes to viral and bacterial infections after an exhaustive exercise bout. Concerning the effect of bacterial endotoxin contact after exhausting exercise in transplant recipients, who are innately immunosuppressed by their medication, no data exists at present. After performing 81 km cycling, including ascending more than 1800 m in altitude, peripheral blood from 10 male kidney transplant recipients and from 10 healthy controls matched for age and gender was obtained. Simulating contact of the athletes with a pathogen post-exercise, the blood samples were incubated with Lipopolysaccharides (LPS). Thereafter microarray analysis was performed. Microarray analysis revealed a markedly oppositional pattern of gene expression in transplant recipients compared with their controls after LPS incubation. Especially immune response genes were significantly over-represented in controls immediately after the exhaustive exercise bout with LPS stimulation, whereas numerous apoptotic genes were over-represented in transplant recipients. Merging our previous data with these recent findings it should be discussed if transplant recipients need to reduce their immunosuppressive medication before performing exhaustive exercise.
Authors:
Ingmar Königsrainer; Markus Löffler; Sarah Bühler; Michael Walter; Luana Schafbuch; Stefan Beckert; Jörg Glatzle; Philipp Horvath; Hinnak Northoff; Silvio Nadalin; Alfred Königsrainer; Derek Zieker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Exercise immunology review     Volume:  18     ISSN:  1077-5552     ISO Abbreviation:  Exerc Immunol Rev     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505535     Medline TA:  Exerc Immunol Rev     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
Department of General Visceral and Transplant Surgery, University of Tuebingen, D-72076 Tuebingen, Germany.
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