| Impact of endothelial dysfunction on left ventricular remodeling after successful primary coronary angioplasty for acute myocardial infarction--analysis by quantitative ECG-gated SPECT--. | |
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MedLine Citation:
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PMID: 16485576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We hypothesized that endothelial cell integrity in the risk area would influence left ventricular remodeling after acute myocardial infarction. PATIENTS AND METHODS: Twenty patients (61 +/- 8 y.o.) with acute myocardial infarction underwent 99mTc-tetrofosmin imaging in the subacute phase and three months after successful primary angioplasty due to myocardial infarction. All patients were administered angiotensin-converting enzyme inhibitor after revascularization. Cardiac scintigraphies with quantitative gated SPECT were performed at the sub-acute stage and again 3 months after revascularization to evaluate left ventricular (LV) remodeling. The left ventricular ejection fraction (EF) and end-systolic and end-diastolic volume (ESV, EDV) were determined using a quantitative gated SPECT (QGS) program. Three months after myocardial infarction, all patients underwent cardiac catheterization examination with coronary endothelial function testing. Bradykinin (BK) (0.2, 0.6, 2.0 microg/min) was administered via the left coronary artery in a stepwise manner. Coronary blood flow was evaluated by Doppler flow velocity measurement. Patients were divided into two groups by BK-response: a preserved endothelial function group (n = 10) and endothelial dysfunction group (n = 10). RESULTS: At baseline, both global function and LV systolic and diastolic volumes were similar in both groups. However, LV ejection fraction was significantly improved in the preserved-endothelial function group, compared with that in the endothelial dysfunction group (42 +/- 10% to 48 +/- 9%, versus 41 +/- 4% to 42 +/- 13%, p < 0.05). LV volumes progressively increased in the endothelial dysfunction group compared to the preserved-endothelial, function group (123 +/- 45 ml to 128 +/- 43 ml, versus 111 +/- 47 ml to 109 +/- 49 ml, p < 0.05). CONCLUSION: In re-perfused acute myocardial infarction, endothelial function within the risk area plays an important role with left ventricular remodeling after myocardial infarction. |
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Authors:
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Shinro Matsuo; Ichiro Nakae; Tetsuya Matsumoto; Minoru Horie |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 20 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-20 Completed Date: 2006-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 57-62 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Endothelium, Vascular / radionuclide imaging* Female Gated Blood-Pool Imaging / methods* Humans Image Interpretation, Computer-Assisted / methods Male Middle Aged Myocardial Infarction / complications, radionuclide imaging*, therapy* Prognosis Tomography, Emission-Computed, Single-Photon / methods* Treatment Outcome Ventricular Dysfunction, Left / etiology, prevention & control*, radionuclide imaging* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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