| Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. | |
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MedLine Citation:
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PMID: 22061620 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Evidence is accumulating that environmental chemicals (ECs) including endocrine-disrupting compounds (EDCs) can alter female reproductive development, fertility and onset of menopause. While not as clearly defined as in the male, this set of abnormalities may constitute an Ovarian Dysgenesis Syndrome with at least some origins of the syndrome arising during foetal development. ECs/EDCs have been shown to affect trophoblast and placental function, the female hypothalamo-pituitary-gonadal axis, onset of puberty and adult ovarian function. The effects of ECs/EDCs are complex, not least because it is emerging that low-level, 'real-life' mixtures of ECs/EDCs may carry significant biological potency. In addition, there is evidence that ECs/EDCs can alter the epigenome in a sexually dimorphic manner, which may lead to changes in the germ line and perhaps even to transgenerational effects. This review summarises the evidence for EC, including EDC, involvement in female reproductive dysfunction, it highlights potential mechanisms of EC action in the female and emphasises the need for further research into EC effects on female development and reproductive function. |
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Authors:
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Paul A Fowler; Michelle Bellingham; Kevin D Sinclair; Neil P Evans; Paola Pocar; Bernd Fischer; Kristina Schaedlich; Juliane-Susanne Schmidt; Maria R Amezaga; Siladitya Bhattacharya; Stewart M Rhind; Peter J O'Shaughnessy |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-28 |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: - ISSN: 1872-8057 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Division of Applied Medicine, Institute of Medical Sciences, Polwarth Building, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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