Document Detail


Impact of early thrombolysis on chest pain score reflecting myocardial ischemia in relation to various markers of ischemic damage. TEAHAT Study Group.
MedLine Citation:
PMID:  8282435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We randomized 352 patients with pain suggestive of acute myocardial infarction who were seen less than 3 h after onset of symptoms to either tissue plasminogen activator or placebo. The impact of treatment on chest pain score was assessed during the first 24 h and related to limitation of final myocardial damage as assessed by various indirect markers. The most marked effect of tissue plasminogen activator was observed in the chest pain score being reduced by 43% in the tissue plasminogen activator group as compared with placebo. Limitation of infarct size with tissue plasminogen activator reached the following percentage values when various methods were used: maximum serum lactate dehydrogenase I activity, 32%; vectorcardiography (QRS vector difference), 20%; electrocardiography (Palmeri score), 20%; ejection fraction, 9%. We conclude that early thrombolysis in acute myocardial infarction reduces the severity of chest pain by nearly 50%. The effect on chest pain is much more marked as compared with the effect on various markers of the final ischemic damage.
Authors:
J Herlitz; M Dellborg; M Hartford; B W Karlson; T Karlsson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  41     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-02-15     Completed Date:  1994-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  123-31     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Sahlgrenska Hospital, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / drug therapy*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Electrocardiography / drug effects
Female
Humans
L-Lactate Dehydrogenase / blood
Male
Middle Aged
Myocardial Infarction / drug therapy*
Myocardial Ischemia / drug therapy*
Pain Measurement*
Stroke Volume / drug effects
Thrombolytic Therapy / methods*
Tissue Plasminogen Activator / administration & dosage*
Vectorcardiography / drug effects
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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