Document Detail


Impact of early statin therapy on development of atrial fibrillation at the acute stage of myocardial infarction: data from the FAST-MI register.
MedLine Citation:
PMID:  20965993     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Atrial fibrillation developing at the acute stage of myocardial infarction is associated with untoward clinical outcomes. The aim of this study was to determine correlations between early statin therapy and atrial fibrillation in acute myocardial infarction.
METHODS: Patients (3396) with sinus rhythm developing acute myocardial infarction were enrolled in the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI).
RESULTS: Atrial fibrillation developed in 7.0% of patients without and 3.9% of patients with early (≤48 h of admission) statin therapy (p<0.001). Multivariable analysis, including the propensity score for early statin treatment, showed that statin therapy was associated with reduced risk of atrial fibrillation (OR 0.64; 95% CI 0.45 to 0.92, p=0.017). Compared to patients without early statin therapy, the OR for atrial fibrillation were 0.72 (0.49 to 1.04, p=0.080), 0.52 (0.28 to 0.95, p=0.034) and 0.40 (0.18 to 0.92, p=0.030) in patients on conventional, intermediate and high doses respectively.
CONCLUSIONS: This study is the first to document a correlation between early statin therapy and atrial fibrillation at the early stage of acute myocardial infarction.
Authors:
Nicolas Danchin; Laurent Fauchier; Eloi Marijon; Claude Barnay; Alain Furber; Philippe Mabo; Paul Bernard; Jean-Jacques Blanc; Xavier Jouven; Jean-Yves Le Heuzey; Bernard Charbonnier; Jean Ferrières; Tabassome Simon;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1809-14     Citation Subset:  AIM; IM    
Affiliation:
Cardiology Department, Hoˆpital Europe´en Georges Pompidou and Universite´ Paris Descartes, Paris, France. nicolas.danchin@egp.aphp.fr
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