Document Detail

Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy.
MedLine Citation:
PMID:  16618360     Owner:  NLM     Status:  MEDLINE    
Polyunsaturated fatty acids (PUFAs) are components of cell membranes and may play an immunomodulating role in the pathogenesis of atopic dermatitis (AD). The goal was to determine the impact of PUFAs on AD by dietary supplementation of infants. Based on the parents' decision on their babies' primary feeding, mothers and newborns were randomized to the supplementation with gamma-linolenic acid (GLA) or placebo for up to 6 months. Breastfed infants received GLA by supplementing their mothers. Formula diet was commercial whey hydrolysate unsupplemented with PUFAs. Of 131 eligible infants, 24 developed AD within the first year of life. Of these, nine belonged to the exclusively breastfed group (n = 58), 14 to the combined-fed group (n = 53), and one to the never breastfed group (n = 20). We could not find an influence of GLA on the development of AD. In subjects with AD, at 1 yr of age the serum-immunoglobulin E (IgE) was the lowest in the GLA-supplemented group A-subjects. In the GLA-supplemented group, GLA-levels in breast milk were similar in atopic and non-atopic infants. In the non-supplemented group the GLA-content of breast milk was 0.07% of total fatty acids in atopic infants vs. 0.17% in non-atopic infants (p < 0.01). Dietary GLA-supplementation could not prevent AD. Interestingly, the number of infants developing AD was the lowest in never breastfed children. In infants suffering from AD, GLA-supplementation seemed to reduce total IgE in the first year of life.
Richard Kitz; Markus A Rose; Heidrun Schönborn; Stefan Zielen; Hans J Böhles
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  17     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2007-03-26     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  112-7     Citation Subset:  IM    
Department of Allergology and Pulmonology, Children's Hospital, Goethe University, Frankfurt, Germany.
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MeSH Terms
Breast Feeding
Dermatitis, Atopic / diet therapy*,  prevention & control
Dietary Fats / administration & dosage,  therapeutic use*
Dietary Supplements
Double-Blind Method
Infant Formula / administration & dosage
Infant, Newborn
gamma-Linolenic Acid / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Dietary Fats; 506-26-3/gamma-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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