Document Detail


Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients.
MedLine Citation:
PMID:  20232045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Selective digestive microbial decontamination (SDD) is hypothesized to benefit patients in intensive care (ICU) by suppressing Gram-negative potential pathogens from the colon without affecting the anaerobic intestinal microbiota. The purpose of this study was to provide more insight to the effects of digestive tract and oropharyngeal decontamination on the intestinal microbiota by means of a prospective clinical trial in which faecal samples were collected from ICU patients for intestinal microbiota analysis.
METHODS: The faecal samples were collected from ICU patients enrolled in a multicentre trial to study the outcome of SDD and selective oral decontamination (SOD) in comparison with standard care (SC). Fluorescent in situ hybridization (FISH) was used to analyze the faecal microbiota. The numbers of bacteria from different bacterial groups were compared between the three regimens.
RESULTS: The total counts of bacteria per gram faeces did not differ between regimens. The F. prausnitzii group of bacteria, representing an important group among intestinal microbiota, was significantly reduced in the SDD regimen compared to the SC and SOD. The Enterobacteriaceae were significantly suppressed during SDD compared to both SOD and SC; enterococci increased in SDD compared to both other regimens.
CONCLUSIONS: The composition of the intestinal microbiota is importantly affected by SDD. The F. prausnitzii group was significantly suppressed during SDD. This group of microbiota is a predominant producer of butyrate, the main energy source for colonocytes. Reduction of this microbiota is an important trade-off while reducing gram-negative bacteria by SDD.
Authors:
Robin F Benus; Hermie J Harmsen; Gjalt W Welling; Rob Spanjersberg; Jan G Zijlstra; John E Degener; Tjip S van der Werf
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-03-16
Journal Detail:
Title:  Intensive care medicine     Volume:  36     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-11-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1394-402     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Antibiotic Prophylaxis
Decontamination / methods*
Feces / microbiology
Gram-Negative Bacteria / drug effects*
Humans
Intensive Care Units*
Intestines / microbiology*
Metagenome / drug effects*
Middle Aged
Netherlands
Oropharynx / microbiology*
Comments/Corrections
Comment In:
Intensive Care Med. 2010 Oct;36(10):1783-4   [PMID:  20607517 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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