Document Detail

Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure.
MedLine Citation:
PMID:  19369874     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Exertional oscillatory ventilation (EOV) occurs in many patients with chronic heart failure. Two different definitions of EOV have been proposed by Corrá and Leite. We aimed to compare the prevalence of EOV and its prognostic significance in patients with chronic heart failure using the two diagnostic approaches. METHODS: Patients underwent a symptom-limited, treadmill-based exercise test with metabolic gas exchange measurements using the modified Bruce protocol. EOV was defined (i) as cyclic fluctuations in ventilation lasting for more than 60% of exercise duration, with an amplitude of greater than 15% of the average amplitude of cyclic fluctuations at rest (Corrá) and/or (ii) as three or more regular oscillations with regularity defined if the standard deviation of three consecutive cycle lengths was within 20% of the average coupled with a minimal average amplitude of ventilatory oscillation of 5 l (Leite). RESULTS: Two hundred and forty patients (mean age 59+/-13 years; 73% males; left ventricular ejection fraction 34+/-6%; peak VO2 21.0+/-4.6 ml/kg per min; VE/VCO2 slope 35+/-9) were included in the study. The prevalence of EOV was 25% using the Corrá method and 31% using the Leite method. Fifty percent of patients diagnosed with EOV by the Corrá criteria and 58% diagnosed by the Leite criteria had died at 12-month follow-up. EOV (Corrá) was a predictor of mortality independent of peak VO2, VE/VCO2 slope, left ventricular ejection fraction, age, and 6-min walk test distance. A hazard ratio (HR) of 6.3 (P<0.0001; 95% confidence interval=1.6-25.2) was evident for the Corrá method, which was higher than for the Leite method (HR=4.9; P<0.0001; 95% confidence interval=2.6-18.2). CONCLUSION: The prevalence of EOV was between 25 and 31% depending on the criteria used to define it. The presence of EOV was a powerful predictor of adverse outcome, and diagnosed with the Corrá criteria was associated with a higher HR than the Leite criteria.
Lee Ingle; Aaron Isted; Klaus K Witte; John G F Cleland; Andrew L Clark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology     Volume:  16     ISSN:  1741-8275     ISO Abbreviation:  Eur J Cardiovasc Prev Rehabil     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-30     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101192000     Medline TA:  Eur J Cardiovasc Prev Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
Carnegie Research Institute, Leeds Metropolitan University, Beckett's Park, Headingley, Leeds, UK.
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MeSH Terms
Cheyne-Stokes Respiration / diagnosis*,  physiopathology*
Chronic Disease
Exercise Test
Heart Failure / physiopathology*
Middle Aged
Oxygen Consumption / physiology
Proportional Hazards Models
Pulmonary Ventilation
Reproducibility of Results
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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