Document Detail


Impact of different clinical variables on pregnancy outcome following embryo cryopreservation.
MedLine Citation:
PMID:  11155958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In our program's 13 years of experience, more than 9000 embryos have been cryopreserved in gonadotropin-stimulated IVF cycles. Over 1500 thaw and transfer cycles have yielded a pregnancy rate of approximately 25%. Different ovarian stimulation regimens (various preparations of FSH. alone or in combination with hMG, with or without concomitant use of a GnRH agonist) did not influence embryo survival or pregnancy rate. Likewise, the application of oocyte/embryo micromanipulation techniques for assisted fertilization (ICSI for male infertility) or assisted hatching (performed selectively) did not have an impact on pregnancy results. Survival and transfer rates of embryos cryopreserved at pronuclear or cleaving stage did not differ significantly. However, implantation and pregnancy rates were higher with pronuclear embryo freezing (day-2 transfers) when compared to embryos frozen at the cleavage stage (day-3 transfers). This may be the result of patient selection and transfer policies. Similar implantation and pregnancy results were achieved in natural and estrogen progesterone supplemented transfer cycles. Initial experience with pronuclear freezing followed by transfer at the blastocyst stage appears to offer a very successful alternative for selected patients.
Authors:
S Oehninger; J Mayer; S Muasher
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  169     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Affiliation:
Department Obstetrics and Gynecology, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk 23507, USA. oehninsc@evms.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Blastocyst / cytology*
Chi-Square Distribution
Cryopreservation / methods*,  standards
Embryo Transfer
Female
Humans
Ovulation Induction / methods,  standards
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Specimen Handling / methods,  standards

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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