Document Detail

Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension.
MedLine Citation:
PMID:  17303471     Owner:  NLM     Status:  MEDLINE    
AIMS: To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients.
METHODS: 439 hypertensive patients were selected for participation in this study. All participants had an echocardiographic evaluation of systolic and diastolic function. The overall degree of diastolic function and specific parameters (e.g. E/Ea ratio) were analysed.
RESULTS: We divided the cohort (63+/-10 years) into those with diabetes mellitus (DM(+), n=124) and without diabetes mellitus (DM(-), n=315). The prevalence of normal diastolic function was lower in DM(+) than DM(-) (19.4% vs. 30.8%); mild (65.3% vs. 60.0%) and moderate/ severe diastolic dysfunction were more frequent in DM(+) (15.3% vs. 9.2%, p=0.022). The E/Ea ratio, an estimate of left ventricular end-diastolic pressure, was significantly higher in DM(+) (12.3+/-4.4) as compared to DM(-) (10.8+/-3.6, p<0.001). Sex-specific analysis revealed that the effect of DM on diastolic function was mainly limited to the male subgroup. Multivariate logistic regression analysis showed that diabetes affected diastolic function in males independent of blood pressure, left ventricular mass index, concomitant medication and prevalence of coronary artery disease.
CONCLUSION: Diabetes negatively affects diastolic function in patients with arterial hypertension. This effect is mainly confined to the male subgroup.
Rolf Wachter; Claus Lüers; Sibylle Kleta; Kerstin Griebel; Christoph Herrmann-Lingen; Lutz Binder; Nico Janicke; Dirk Wetzel; Michael M Kochen; Burkert Pieske
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-15
Journal Detail:
Title:  European journal of heart failure     Volume:  9     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-09-20     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  469-76     Citation Subset:  IM    
Department of Cardiology and Pneumology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
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MeSH Terms
Blood Pressure / drug effects
Case-Control Studies
Confounding Factors (Epidemiology)
Coronary Artery Disease / complications,  epidemiology,  physiopathology
Diabetes Mellitus, Type 2 / complications*,  drug therapy,  physiopathology
Echocardiography, Doppler
Hypertension / complications*,  epidemiology,  etiology,  physiopathology
Hypoglycemic Agents / adverse effects
Logistic Models
Middle Aged
Multivariate Analysis
Severity of Illness Index
Sex Factors
Stroke Volume / drug effects
Ventricular Dysfunction, Left / epidemiology,  etiology,  physiopathology*
Ventricular Function, Left* / drug effects
Reg. No./Substance:
0/Hypoglycemic Agents

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