| Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension. | |
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MedLine Citation:
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PMID: 17303471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients. METHODS: 439 hypertensive patients were selected for participation in this study. All participants had an echocardiographic evaluation of systolic and diastolic function. The overall degree of diastolic function and specific parameters (e.g. E/Ea ratio) were analysed. RESULTS: We divided the cohort (63+/-10 years) into those with diabetes mellitus (DM(+), n=124) and without diabetes mellitus (DM(-), n=315). The prevalence of normal diastolic function was lower in DM(+) than DM(-) (19.4% vs. 30.8%); mild (65.3% vs. 60.0%) and moderate/ severe diastolic dysfunction were more frequent in DM(+) (15.3% vs. 9.2%, p=0.022). The E/Ea ratio, an estimate of left ventricular end-diastolic pressure, was significantly higher in DM(+) (12.3+/-4.4) as compared to DM(-) (10.8+/-3.6, p<0.001). Sex-specific analysis revealed that the effect of DM on diastolic function was mainly limited to the male subgroup. Multivariate logistic regression analysis showed that diabetes affected diastolic function in males independent of blood pressure, left ventricular mass index, concomitant medication and prevalence of coronary artery disease. CONCLUSION: Diabetes negatively affects diastolic function in patients with arterial hypertension. This effect is mainly confined to the male subgroup. |
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Authors:
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Rolf Wachter; Claus Lüers; Sibylle Kleta; Kerstin Griebel; Christoph Herrmann-Lingen; Lutz Binder; Nico Janicke; Dirk Wetzel; Michael M Kochen; Burkert Pieske |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-15 |
Journal Detail:
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Title: European journal of heart failure Volume: 9 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-17 Completed Date: 2007-09-20 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 469-76 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Pneumology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / drug effects Case-Control Studies Confounding Factors (Epidemiology) Coronary Artery Disease / complications, epidemiology, physiopathology Diabetes Mellitus, Type 2 / complications*, drug therapy, physiopathology Echocardiography, Doppler Female Humans Hypertension / complications*, epidemiology, etiology, physiopathology Hypoglycemic Agents / adverse effects Logistic Models Male Middle Aged Multivariate Analysis Prevalence Severity of Illness Index Sex Factors Stroke Volume / drug effects Ventricular Dysfunction, Left / epidemiology, etiology, physiopathology* Ventricular Function, Left* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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