Document Detail

Impact of delirium on distress, health-related quality of life, and cognition 6 months and 1 year after hematopoietic cell transplant.
MedLine Citation:
PMID:  20100587     Owner:  NLM     Status:  MEDLINE    
Delirium commonly occurs during myeloablative hematopoietic cell transplantation (HCT). Little is known about how delirium during the acute phase of HCT affects long-term distress, health-related quality of life (HRQOL), and neurocognitive functioning. This prospective, cohort study examines these outcomes at 6 months and 1 year in 90 patients undergoing HCT. Patients completed a battery assessing distress, HRQOL, and subjective neuropsychological functioning before receiving their first HCT as well as at 6 months and 1 year. Patients with a delirium episode within the 4 weeks after HCT had significantly more distress and fatigue at 6 months (P < .004) and at 1 year (P < .03), compared with patients without delirium. At 1 year, patients with delirium also had worse symptoms of depression and post traumatic stress (P < .03). Patients with delirium had worse physical health on the SF-12 at 6 months (P < .03) and worse mental health on the SF-12 at 1 year (P < .03). At both 6 months and 1 year, patients with delirium after HCT reported worse memory (P < .009) and executive functioning (P < .006). Delirium during the acute phase of HCT is significantly associated with persistent distress, decreased HRQOL, and subjective neurocognitive dysfunction at both 6 months and 1 year.
James R Basinski; Catherine M Alfano; Wayne J Katon; Karen L Syrjala; Jesse R Fann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     Volume:  16     ISSN:  1523-6536     ISO Abbreviation:  Biol. Blood Marrow Transplant.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600628     Medline TA:  Biol Blood Marrow Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  824-31     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98125, USA.
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MeSH Terms
Anxiety / diagnosis,  etiology
Breast Neoplasms / psychology,  therapy
Cognition Disorders / diagnosis,  etiology*
Delirium / complications*,  diagnosis,  epidemiology
Depression / diagnosis,  etiology
Fatigue / diagnosis,  etiology
Follow-Up Studies
Graft vs Host Disease
Hematologic Neoplasms / psychology,  surgery
Hematopoietic Stem Cell Transplantation / adverse effects*,  psychology
Memory Disorders / diagnosis,  etiology
Middle Aged
Mood Disorders / diagnosis,  etiology
Ovarian Neoplasms / psychology,  therapy
Psychiatric Status Rating Scales
Quality of Life / psychology*
Stress Disorders, Post-Traumatic / diagnosis,  etiology
Stress, Psychological / diagnosis,  etiology*
Treatment Outcome
Young Adult
Grant Support

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