Document Detail

Impact of degradation products of sulfamethoxazole on mammalian cultured cells.
MedLine Citation:
PMID:  18247415     Owner:  NLM     Status:  MEDLINE    
Sulfamethoxazole (SMX) is a widely used antibiotic which has been detected in surface water samples in the ng/L range and also detected in drinking water samples. To limit the environmental impact, ozonation treatment of waste streams has been proposed. However, the degradation products created by ozonation as well as their toxicity have not been reported. In this study, we investigated the degradation products of SMX formed during ozonation and the effects of these products on mammalian cultured cells. In addition to alcohols and nitrates, sulfanilamide was identified as the larger molecular weight compound of the degradation products detected. Cells exposed to the degradation products of SMX maintained their polyhedral geometry longer than the control cells. Proliferation of the cells exposed to the degradation products was not negatively affected when compared with the control cells. The results of this study show that bioactive degradation products can be formed by ozonation of SMX.
Viviane Yargeau; Jennifer Caitlin Huot; Angela Rodayan; Leonie Rouleau; Ranjan Roy; Richard L Leask
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology     Volume:  23     ISSN:  1522-7278     ISO Abbreviation:  Environ. Toxicol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100885357     Medline TA:  Environ Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  492-8     Citation Subset:  IM    
Department of Chemical Engineering, McGill University, Montreal, Canada.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  toxicity*
Cell Line, Tumor
Molecular Structure
Oxidants, Photochemical
Ozone / chemistry
Sulfamethoxazole / chemistry*,  toxicity*
Time Factors
Water Pollutants, Chemical / chemistry,  toxicity
Water Purification
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Oxidants, Photochemical; 0/Water Pollutants, Chemical; 10028-15-6/Ozone; 723-46-6/Sulfamethoxazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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