| Impact of decreased renal function on coagulation and fibrinolysis in patients with non-valvular atrial fibrillation. | |
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MedLine Citation:
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PMID: 19346661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prothrombotic state in non-valvular atrial fibrillation (NVAF) increases the risk of thromboembolic events. It is also well known that a prothrombotic state exists in renal failure. Hemostatic disorders play a role in thromboembolic mortality in both NVAF and renal failure. However, little is known about the influence of renal function on hemostasis in patients with NVAF. METHODS AND RESULTS: A total of 190 consecutive outpatients with NVAF who were not receiving anticoagulant therapy were enrolled in the present study. Patients were stratified in groups based on estimated glomerular filtration rate (eGFR). Plasma concentrations of thrombin-antithrombin complex (TAT) and D-dimer were measured and the influence of renal function on coagulation and fibrinolysis was assessed. A relatively weak and inverse relationship of eGFR to TAT and D-dimer was observed (r=0.28, P=0.0001; r=0.30, P<0.0001). Both mean TAT and D-dimer concentrations in groups gradually and significantly increased as eGFR decreased (P<0.0001). On multivariate regression analysis, decreased eGFR concentration was a significant predictor for elevation of TAT (P<0.05) and D-dimer (P<0.01) in patients with NVAF. CONCLUSIONS: The enhanced coagulation activation appeared to be related to a reduction in residual renal function in patients with NVAF. This suggests that decreased renal function might be a candidate predictor of thromboembolic events in patients with NVAF. |
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Authors:
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Hideki Tanaka; Masahiro Sonoda; Katsuro Kashima; Yasuhiro Tanaka; Kazuhiko Nakamura; Norihito Nuruki; Hirohito Tsubouchi |
Publication Detail:
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Type: Journal Article Date: 2009-04-06 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 846-50 Citation Subset: IM |
Affiliation:
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The Second Department of Cardiology, National Hospital Organization Kagoshima Medical Center, Japan. tanakahi@kagomc2.hosp.go.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antithrombin III Atrial Fibrillation / blood, complications*, physiopathology Biological Markers / blood Blood Coagulation* Female Fibrin Fibrinogen Degradation Products / analysis Fibrinolysis* Glomerular Filtration Rate Humans Kidney / physiopathology* Kidney Diseases / blood, complications*, physiopathology Linear Models Male Middle Aged Peptide Hydrolases / blood Risk Assessment Risk Factors Thrombosis / blood, etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/antithrombin III-protease complex; 0/fibrin fragment D; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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