Document Detail

Impact of culprit plaque composition on the no-reflow phenomenon in patients with acute coronary syndrome: an intravascular ultrasound radiofrequency analysis.
MedLine Citation:
PMID:  18654006     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The difference in the culprit plaque composition of acute coronary syndrome (ACS) patients with and without the no-reflow phenomenon has not been fully evaluated. METHODS AND RESULTS: Intravascular ultrasound radiofrequency data of culprit plaques were obtained and analyzed in 49 ACS patients. The no-reflow phenomenon was defined as a decrease of at least 1 grade in 'Thrombolysis In Myocardial Infarction' flow immediately after mechanical dilatation compared with before mechanical dilatation, with no evidence of thrombus, spasm, or dissection. The no-reflow phenomenon was observed in 9 individuals. Culprit plaques with the no-reflow phenomenon contained a higher percentage of necrotic core component and a smaller percentage of fibrous component than plaques in the patients without the no-reflow phenomenon (necrotic core component, 22.1+/-9.3% vs 11.7+/-7.9%, p=0.0011; fibrous component, 59.6+/-11.2% vs 68.3+/-10.2%, p=0.027). Multivariate analysis identified the percentage of necrotic core component as an independent predictor of the no-reflow phenomenon after adjustment for plaque geometry and procedural factors (odds ratio, 1.7; 95% confidence interval, 1.1 to 2.5; p=0.015). CONCLUSION: Culprit plaques of patients with the no-reflow phenomenon differ from those in patients without the no-reflow phenomenon.
Yasutomi Higashikuni; Kengo Tanabe; Shuzou Tanimoto; Jiro Aoki; Hirosada Yamamoto; Gaku Nakazawa; Ruri Chihara; Yoshinobu Onuma; Shuji Ohtsuki; Atsuhiko Yagishita; Sen Yachi; Hiroyoshi Nakajima; Kazuhiro Hara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1235-41     Citation Subset:  IM    
Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
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MeSH Terms
Acute Coronary Syndrome / etiology,  physiopathology,  therapy,  ultrasonography*
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Artery Disease / complications,  physiopathology,  therapy,  ultrasonography*
Coronary Circulation*
Logistic Models
Middle Aged
No-Reflow Phenomenon / etiology,  physiopathology,  therapy,  ultrasonography*
Odds Ratio
Risk Assessment
Risk Factors
Ultrasonography, Interventional*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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