Document Detail

Impact of coronary collateral circulation on QT dispersion in patients with coronary artery disease.
MedLine Citation:
PMID:  17047446     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to assess the effect of coronary collateral circulation (CCC) on QT dispersion (QTD) in coronary artery disease. BACKGROUND: A prolonged QTD has been linked to increased heterogeneity of ventricular repolarization implicated in the genesis of ventricular arrhythmias and has been associated with an adverse prognosis in patients with coronary artery disease. METHOD: CCC and corrected QTD (QTcD) were established in patients who had at least 85% stenosis in the left anterior descending coronary artery or in proximal part or in the body of the right coronary artery. Furthermore, left ventricular function score was determined for all the patients. RESULTS: While CCC was not present (CCC grade 0) in 32 patients, 68 patients were observed with CCC (CCC grade > or =1). Mean QTcD was higher in patients who had CCC grade > or =1 than in patients with grade 0 (64.3+/-3.5 and 46.8+/-2.7, respectively, P=0.002). We detected a significant correlation between the collateral score and QTcD (r=0.354, P=0.001). CCC grade > or =1 patients had higher mean left ventricular function scores than grade 0 patients (P=0.048). Left ventricular function score and QTcD were observed to be correlated (r=0.200, P=0.046). CONCLUSION: CCC in chronic coronary artery disease was not established to have a positive decreasing effect on QTcD. On the contrary, QTcD values were observed to be even higher in patients with well developed CCC. Further research including larger series and long-term follow-up is required to investigate this issue.
Izzet Tandogan; Halil Aslan; Yuksel Aksoy; Ergun Topal; Okan Turgut; Ahmet Yilmaz; Nusret Acikgoz; Feridun Kosar; Ramazan Ozdemir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  17     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2007-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  623-8     Citation Subset:  IM    
Department of Cardiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Chronic Disease
Collateral Circulation*
Coronary Angiography
Coronary Artery Disease / physiopathology*,  radiography
Coronary Circulation*
Middle Aged
Prospective Studies
Risk Factors
Severity of Illness Index
Ventricular Function, Left / physiology

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