Document Detail

Impact of coronary artery disease on left ventricular ejection fraction recovery following transcatheter aortic valve implantation.
MedLine Citation:
PMID:  25115215     Owner:  NLM     Status:  Publisher    
METHODS: All patients with LVEF≤50% who underwent TAVI between March 2006 and May 2012 were included in the study. The presence and severity of coronary artery disease was measured using the Duke Myocardial Jeopardy Score (DMJS). A DMJS=0 corresponds to patients without CAD or complete revascularization and a DMJS>0 to those with incomplete revascularization. LVEF recovery was assessed by transthoracic echocardiography, measuring the change in LVEF from baseline to 3-months post-TAVI. Myocardial viability was evaluated in a subgroup of patients using cardiac magnetic resonance (CMR) imaging pre-TAVI.
RESULTS: Fifty-six patients were included in the study. Twenty-eight patients (50%) had a DMJS>0. At 3 months, patients with incomplete revascularization (DMJS>0) demonstrated less LVEF recovery post-TAVI (2.0±9.2% versus 11.7±8.9% if DMJS=0;p=0.001). On multivariate analysis, DMJS and presence of significant delayed-enhancement were found to be independent predictors of LVEF recovery. Patients with incomplete revascularization exhibited a worse prognosis with higher mortality at 30-days (22.2% versus 0% if DMJS=0;p=0.010) and 1-year (25.9% versus 3.5% if DMJS=0;p=0.019).
CONCLUSIONS: The present study demonstrates an independent association between incomplete revascularization and decreased LVEF recovery in patients with left ventricular dysfunction undergoing TAVI for severe aortic stenosis. © 2014 Wiley Periodicals, Inc.
Xavier Freixa; Jason Chan; Raoul Bonan; Ragui Ibrahim; Yoan Lamarche; Philippe Demers; Arsène Basmadjian; Réda Ibrahim; Raymond Cartier; Anita W Asgar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-12
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc., a Wiley company.
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