Document Detail

Impact of coronary artery calcification in hemodialysis patients: Risk factors and associations with prognosis.
MedLine Citation:
PMID:  20345389     Owner:  NLM     Status:  MEDLINE    
The risk factors of coronary artery calcification (CAC) and the impact of CAC on cardiovascular events, cardiovascular deaths, and all-cause deaths in hemodialysis (HD) patients have not been fully elucidated. We examined the CAC score (CACS) in 74 HD patients using electron-beam computed tomography. Fifty-six patients underwent a second electron-beam computed tomography after a 15-month interval to evaluate CAC progression. We evaluated (1) the risk factors for CAC and its progression and (2) the impact of CAC on the prognosis. In the cross-sectional study, HD vintage and high-sensitive C-reactive protein (hsCRP) were the independent risk factors for CAC. In the prospective cohort study, delta CACS (progression of CAC) was significantly correlated with hsCRP, fibrinogen, and serum calcium level in the univariate analysis. Stepwise multiple regression analysis revealed that only hsCRP was the independent risk factor for CAC progression in HD patients. Kaplan-Meier survival analysis revealed that cardiovascular events (P<0.0001), cardiovascular deaths (P=0.039), and all-cause deaths (P=0.026) were significantly associated with CACS. In conclusion, CAC had significantly progressed in HD patients during the 15-month observation period. Microinflammation was the only independent risk factor for CAC progression in HD patients. The advanced CAC was a significant prognostic factor in HD patients, i.e., which was strongly associated with future cardiovascular events, cardiovascular deaths, and all-cause deaths.
Takayasu Ohtake; Kunihiro Ishioka; Kenjiro Honda; Machiko Oka; Kyoko Maesato; Tsutomu Mano; Ryota Ikee; Hidekazu Moriya; Sumi Hidaka; Shuzo Kobayashi
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Publication Detail:
Type:  Journal Article     Date:  2010-03-24
Journal Detail:
Title:  Hemodialysis international. International Symposium on Home Hemodialysis     Volume:  14     ISSN:  1542-4758     ISO Abbreviation:  Hemodial Int     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093910     Medline TA:  Hemodial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  218-25     Citation Subset:  IM    
Department of Nephrology, Kidney & Dialysis Center, Shonan Kamakura General Hospital, Kamakura, Japan. <>
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MeSH Terms
C-Reactive Protein / metabolism
Calcinosis / mortality*,  radiography
Calcium / blood
Cohort Studies
Coronary Artery Disease / mortality*,  radiography
Cross-Sectional Studies
Disease Progression
Fibrinogen / metabolism
Kaplan-Meiers Estimate
Kidney Failure, Chronic / mortality*,  therapy
Middle Aged
Models, Biological
Prospective Studies
Regression Analysis
Renal Dialysis / mortality*,  statistics & numerical data
Risk Factors
Tomography, X-Ray Computed / methods
Vasculitis / mortality,  radiography
Reg. No./Substance:
7440-70-2/Calcium; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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