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Impact of congenital heart disease on brain development in newborn infants.
MedLine Citation:
PMID:  22529596     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess brain development and brain injury in neonates with cyanotic and acyanotic congenital heart disease (CHD).
METHODS: The study included 52 term infants with CHD who were divided into two groups: Cyanotic (n=21) and acyanotic (n=31). Fifteen healthy neonates of matched age and sex were enrolled in the study as controls. Three-dimensional proton magnetic resonance spectroscopic imaging and diffusion tensor imaging were used to assess brain development and injury. We calculated the ratio of N-acetylaspartate (NAA) to choline (which increases with maturation), average diffusivity (which decreases with maturation), fractional anisotropy of white matter (which increases with maturation), and the ratio of lactate to choline (which increases with brain injury).
RESULTS: As compared with control neonates, those with CHD had significant decrease in NAA/choline ratio (P<0.001), significant increase in lactate/choline ratio (P<0.0001), significant increase in average diffusivity (P<0.0001), and significant decrease of white matter fractional anisotropy (P<0.001). Neonates with cyanotic CHD had significant less brain development and more brain injury than those with acyanotic CHD (P<0.05).
CONCLUSIONS: Newborn infants with cyanotic and acyanotic CHD are at high risk of brain injury and impaired brain maturity.
Authors:
Moustafa M Abdel Raheem; Walid A Mohamed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of pediatric cardiology     Volume:  5     ISSN:  0974-5149     ISO Abbreviation:  Ann Pediatr Cardiol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101495459     Medline TA:  Ann Pediatr Cardiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt, Department of Pediatrics, College of Medicine, King Khalid University, Abha, Saudi Arabia.
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