Document Detail


Impact of conceptus mass on glucose disposal rate in pregnant women.
MedLine Citation:
PMID:  8476029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of an increasing fetal and placental mass on maternal glucose disposal rate (GDR) was studied in 17 pregnant women. Eleven pregnancies were singleton pregnancies, five were twin and one was a triplet pregnancy. Both the maternal fasting glucose concentration [Glc] and the total fetal and placental weight (W) were significantly correlated with an increased maternal GDR. Glucose concentration and conceptus weight were interdependent. The multiple linear regression of glucose disposal rate on glucose concentration and total weight is given by GDR = -1.573 + 0.176W + 0.932[Glc] +/- 0.24, r2 = 0.52, P < 0.01. These data are utilized to estimate the glucose utilization rate of the human conceptus at a fasting glucose concentration of 3.9 mM with a range of 10-15 mg.kg-1.min-1. Maternal GDR increases with increasing glucose concentration at a rate similar to that reported for newborn infants, consistent with a high glucose utilization by the uterus.
Authors:
A M Marconi; E Davoli; I Cetin; A Lanfranchi; G Zerbe; R Fanelli; P V Fennessey; G Pardi; F C Battaglia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-17     Completed Date:  1993-05-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E514-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, San Paolo Institute of Biomedical Sciences, University of Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Blood Glucose / metabolism
Female
Gestational Age
Glucose / metabolism*
Humans
Infant, Newborn
Kinetics
Organ Size
Placenta / anatomy & histology,  physiology*
Pregnancy / metabolism*
Pregnancy, Multiple / metabolism*
Regression Analysis
Triplets
Twins
Grant Support
ID/Acronym/Agency:
HD-20761/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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