Document Detail


Impact of common thrombophilias and JAK2 V617F on pregnancy outcomes in unselected Italian women.
MedLine Citation:
PMID:  21232003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although an association between thrombophilias and adverse pregnancy outcome has been shown, the influence of the most common inherited thrombophilias and the somatic mutation JAK2 V617F in determining an adverse outcome is questioned.
OBJECTIVES: We examined the contribution of the factor V Leiden (FVL), the prothrombin G20210A (PTm) and the somatic JAK2 V617F mutations to adverse pregnancy outcome in an unselected cohort of pregnant women.
PATIENTS/METHODS: During the study period, 5345 pregnant women were admitted to the 14 hospitals of the five provinces of the Campania region (Italy). Of these, 3097 samples were investigated and obstetric history collected. The presence of the FVL, PTm, and JAK2 V617F mutation was prospectively determined by polymerase chain reaction followed by TaqMan SNP genotyping assays.
RESULTS AND CONCLUSIONS: We identified 119 (3.8%) women that carried FVL and 138 (4.4%) with the PTm. Only 4 (0.1%) women carried both mutations. Only one woman tested positive for the JAK2 V617F somatic mutation. The prevalence of a previous history of an adverse pregnancy outcome was similar in women with common thrombophilias as compared to those without. In the current pregnancy, there was no association of any of the genetic markers considered with any of the adverse outcomes investigated. Carriership of FVL or PTm showed a positive trend with delivery of a small for gestational age newborn (OR: 1.5, 95% CI: 0.9-2.5). Pregnancy outcomes in asymptomatic women with inherited thrombophilias are often uneventful. Therefore, in women at low-risk of an adverse pregnancy, neither screening for common thrombophilias nor administration of routine thromboprophylaxis are warranted.
Authors:
E Grandone; D Colaizzo; G Tiscia; P Vergura; F Cappucci; L Greco; M Margaglione; P Martinelli;
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  9     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-06-21     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  496-501     Citation Subset:  IM    
Copyright Information:
© 2011 International Society on Thrombosis and Haemostasis.
Affiliation:
Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia, Italy. e.grandone@operapadrepio.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amino Acid Substitution
Cohort Studies
Factor V / genetics
Female
Heterozygote
Humans
Infant, Newborn
Infant, Small for Gestational Age
Italy
Janus Kinase 2 / genetics*
Middle Aged
Mutation, Missense*
Pregnancy
Pregnancy Complications, Hematologic / blood,  genetics*
Pregnancy Outcome
Prospective Studies
Prothrombin / genetics
Risk Factors
Thrombophilia / blood,  complications*,  genetics*
Young Adult
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human
Investigator
Investigator/Affiliation:
R Arienzo / ; C Ricco / ; A Fasolino / ; G Colarieti / ; M Di Matteo / ; C Balbi / ; A Menditto / ; G Calabria / ; C Malzoni / ; A Malzoni / ; R Picone / ; I Ardovino / ; P Luciano / ; P Mignano / ; A Agangi / ; P Puggina / ; F Carlomagno / ; A Barone / ; L Di Prisco / ; R Zito / ; G Cobellis / ; T Guerritore / ; P Iervolino / ; G Trezza / ; G Auriemma / ; F Morelli / ; A Fusco / ; D Acierno / ; C Ciccone / ; P Martinelli / ; M Pecoraro / ; G M Maruotti /

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