Document Detail

Impact of colostomy on intestinal microflora and bacterial translocation in young rats fed with heat-killed Lactobacillus acidophilus strain LB.
MedLine Citation:
PMID:  18481224     Owner:  NLM     Status:  MEDLINE    
A rat animal model of left colostomy was found to significantly impair the growth curve of rats. Assessment of the intestinal flora showed that colostomy mostly affects the cecal but not colonic microflora. Generally, the number of enterococci was increased in both ileum and cecum; cecal lactobacilli also rose, accounting for a promotion of lactic acid bacteria in colostomised rats. No significant differences between colostomised, laparotomised and control rats could be observed for the translocation of intestinal bacteria to internal organs of rats (i.e. spleen, kidneys, lungs or liver), whatever their diet. Heat-killed Lactobacillus acidophilus strain LB administration (dead probiotic bacteria) tended to exhibit a stimulatory effect on bifidobacteria, probably affecting the culture-medium fermentation substances included in the pharmaceutical product. This effect was abolished by laparotomy and colostomy. A trend towards a probiotic-like effect, not susceptible to colostomy, was also witnessed as counts of lactobacilli tended to increase in both cecum and colon of all animals fed with L. acidophilus LB.
K Rigon-Zimmer; C Mullié; A Tir-Touil-Meddah; P Buisson; L Léké; J P Canarelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-15
Journal Detail:
Title:  Folia microbiologica     Volume:  53     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Faculté de Pharmacie, Université de Picardie Jules Verne, 80037, Amiens Cedex 1, France.
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MeSH Terms
Bacterial Physiological Phenomena*
Bacterial Translocation*
Colonic Diseases / microbiology,  surgery*
Colostomy / adverse effects*
Hot Temperature
Intestines / microbiology*
Lactobacillus acidophilus / metabolism*
Models, Animal
Rats, Wistar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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