| Impact of co administration of selenium and quinolinic acid in the rat's brain. | |
| | |
MedLine Citation:
|
PMID: 19464274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of two different doses (1 microg and 50 microg Se/100 g body wt) of selenium on quinolinic acid toxicity was investigated in rat's brain. Male albino rats were maintained for 60 days as follows: (1) control group (normal diet), (2) Quinolinic acid group (55 microg/100 g body wt)/day, (3) high dose selenium (50 microg/100 g body wt)/day, (4) high dose selenium ((50 microg/100 g body wt) + Quinolinic acid (55 microg/100 g body wt)/day (5) low dose selenium (1 microg/100 g body wt)/day and (6) low dose selenium (1 microg/100 g body wt) + Quinolinic acid (55 microg/100 g body wt)/day. Results revealed that quinolinic acid intake lead to an increase in the oxidative stress as evidenced by decreased activity of antioxidant enzymes (SOD, catalase and GR), increased amount of lipid peroxidation products (MDA,HP and CD) and free fatty acids compared to control group. Co administration of selenium at a dose of 1 microg/100 g body wt along with quinolinic acid had reduced the oxidative stress induced by quinolinic acid and it also led to a change in the brain architecture as evidenced by the decreased activity of acetyl cholinesterase and decreased concentration of neurotransmitters. Histopathological studies revealed that selenium at a dose of 1 microg was more effective in reducing the oxidative stress and higher dose of selenium was toxic. |
| | |
Authors:
|
S Sreekala; M Indira |
Related Documents
:
|
957814 - On the visualization of central dopamine and noradrenaline nerve terminals in cryostat ... 17176634 - Resveratrol can only partially attenuate ethanol-induced oxidative stress in embryonic ... 2285994 - Study on the biodistribution of deuterated biomolecules in mice aiming at new diagnosti... 16867364 - Analysis of tryptophan, tyrosine and related dipeptides in mouse brain by isocratic hig... 15152994 - Synthesis of cyclic peptidosulfonamides by ring-closing metathesis. 21524944 - D-aspartate-an important bioactive substance in mammals: a review from an analytical an... |
Publication Detail:
|
Type: Journal Article Date: 2009-05-21 |
Journal Detail:
|
Title: Brain research Volume: 1281 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-07-06 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 101-7 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholinesterase
/
metabolism Animals Biogenic Monoamines / metabolism Brain / drug effects*, metabolism, pathology Catalase / metabolism Fatty Acids, Nonesterified / metabolism Glutathione Peroxidase / metabolism Glutathione Reductase / metabolism Lipid Peroxidation / drug effects Male Malondialdehyde / metabolism Neurotoxins / administration & dosage, toxicity* Oxidative Stress / drug effects Quinolinic Acid / administration & dosage, toxicity* Rats Rats, Sprague-Dawley Selenium / administration & dosage, toxicity* Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Biogenic Monoamines; 0/Fatty Acids, Nonesterified; 0/Neurotoxins; 542-78-9/Malondialdehyde; 7782-49-2/Selenium; 89-00-9/Quinolinic Acid; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.
Next Document: Assessing functional outcomes following intracerebral hemorrhage in rats.