Document Detail

Impact and clinical significance of recurrent venous thromboembolism.
MedLine Citation:
PMID:  20632262     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this review was to analyse current knowledge and controversies associated with the diagnosis, treatment and prevention of recurrent venous thromboembolism (VTE). METHODS: MEDLINE and manual searches were performed to select prospective papers on the diagnosis, treatment and prevention of recurrent VTE for their relevance and quality. RESULTS: The cumulative incidence of recurrent VTE increases from 11 per cent at 1 year to 40 per cent at 10 years. The incidence of recurrence is higher in unprovoked thrombosis compared with provoked VTE. Patients with unprovoked deep vein thrombosis also have a greater number of multiple recurrences. Ultrasonography or D-dimer monitoring may have an impact on the duration of anticoagulation but further refinements are needed. The incidence of skin damage is higher in ipsilateral recurrence compared with contralateral or no recurrence. Legs with ipsilateral recurrence more often have both reflux and obstruction. CONCLUSION: The role and weight of the predictive factors for recurrent VTE and its sequelae, and the type and optimal duration of anticoagulation have not been studied adequately. Fatality associated with pulmonary embolism and rates of recurrent VTE remain unacceptably high.
N Labropoulos; G Spentzouris; A P Gasparis; M Meissner
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of surgery     Volume:  97     ISSN:  1365-2168     ISO Abbreviation:  Br J Surg     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  989-99     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Copyright 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Stony Brook University Medical Center, Stony Brook, New York, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Diagnostic Imaging
Embolism, Paradoxical / etiology
Fibrin Fibrinogen Degradation Products / metabolism
Medication Adherence
Physical Examination
Prospective Studies
Pulmonary Embolism / etiology
Risk Factors
Venous Thromboembolism* / diagnosis,  epidemiology,  prevention & control,  therapy
Reg. No./Substance:
0/Anticoagulants; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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