Document Detail


Impact of circulating bone-resorbing cytokines on the subsequent bone loss following bone marrow transplantation.
MedLine Citation:
PMID:  15170175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines including IL-6 and TNF-alpha play an important role in the pathogenesis of postmenopausal osteoporosis. However, the relationship between changes in the cytokine levels and subsequent bone loss in patients undergoing a bone marrow transplantation (BMT) is unclear. A total of 46 patients undergoing an allogeneic BMT were prospectively investigated. The bone turnover markers and the serum cytokines were measured before BMT and serially after BMT. Bone mineral density (BMD) was measured before and 1 year after BMT. At 1 year after BMT, the lumbar spine BMD had decreased by 4.8%, and the total proximal femoral BMD had decreased by 12.3%. The serum IL-6 and TNF-alpha levels increased until 2 and 3 weeks after BMT, respectively. The lumbar BMD was significantly decreased as the serum IL-6 and TNF-alpha levels increased by post-BMT 3 weeks. The lumbar BMD decreased significantly as the cumulative prednisolone and cyclosporine dose increased. Patients with GVHD > or =grade II had higher lumbar bone loss than patients with GVHD <grade I. In conclusion, immunosuppressants, GVHD occurrence and increase in bone-resorbing cytokines in the early post-BMT period were associated with later bone loss after BMT. Further studies are needed to elucidate the precise mechanism.
Authors:
W-Y Lee; K-H Baek; E-J Rhee; H-J Tae; K-W Oh; M-I Kang; K-W Lee; S-W Kim; C-C Kim; E-S Oh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  34     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-21     Completed Date:  2005-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Affiliation:
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Bone Density
Bone Marrow Transplantation / adverse effects*
Bone Resorption / chemically induced,  etiology*
Cohort Studies
Cyclosporine / adverse effects,  therapeutic use
Cytokines / blood,  physiology*
Female
Graft vs Host Disease / complications
Humans
Immunosuppressive Agents / adverse effects
Interleukin-6 / blood
Male
Prednisolone / adverse effects,  therapeutic use
Prospective Studies
Tumor Necrosis Factor-alpha / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Immunosuppressive Agents; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine

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