Document Detail

Impact of circulating bone-resorbing cytokines on the subsequent bone loss following bone marrow transplantation.
MedLine Citation:
PMID:  15170175     Owner:  NLM     Status:  MEDLINE    
Cytokines including IL-6 and TNF-alpha play an important role in the pathogenesis of postmenopausal osteoporosis. However, the relationship between changes in the cytokine levels and subsequent bone loss in patients undergoing a bone marrow transplantation (BMT) is unclear. A total of 46 patients undergoing an allogeneic BMT were prospectively investigated. The bone turnover markers and the serum cytokines were measured before BMT and serially after BMT. Bone mineral density (BMD) was measured before and 1 year after BMT. At 1 year after BMT, the lumbar spine BMD had decreased by 4.8%, and the total proximal femoral BMD had decreased by 12.3%. The serum IL-6 and TNF-alpha levels increased until 2 and 3 weeks after BMT, respectively. The lumbar BMD was significantly decreased as the serum IL-6 and TNF-alpha levels increased by post-BMT 3 weeks. The lumbar BMD decreased significantly as the cumulative prednisolone and cyclosporine dose increased. Patients with GVHD > or =grade II had higher lumbar bone loss than patients with GVHD <grade I. In conclusion, immunosuppressants, GVHD occurrence and increase in bone-resorbing cytokines in the early post-BMT period were associated with later bone loss after BMT. Further studies are needed to elucidate the precise mechanism.
W-Y Lee; K-H Baek; E-J Rhee; H-J Tae; K-W Oh; M-I Kang; K-W Lee; S-W Kim; C-C Kim; E-S Oh
Related Documents :
18679745 - Role of activated protein c on wound healing process in left colonic anastomoses in the...
18043735 - Transforming growth factor: beta signaling is essential for limb regeneration in axolotls.
9795335 - Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene ...
3724705 - Abnormal relationship between serum phosphate concentration and renal 25-hydroxycholeca...
385895 - Effects of repeated exposures to peak concentrations of nitrogen dioxide and ozone on r...
14500645 - Genetic control of tolerance to type ii collagen and development of arthritis in an aut...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  34     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-21     Completed Date:  2005-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Bone Density
Bone Marrow Transplantation / adverse effects*
Bone Resorption / chemically induced,  etiology*
Cohort Studies
Cyclosporine / adverse effects,  therapeutic use
Cytokines / blood,  physiology*
Graft vs Host Disease / complications
Immunosuppressive Agents / adverse effects
Interleukin-6 / blood
Prednisolone / adverse effects,  therapeutic use
Prospective Studies
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Immunosuppressive Agents; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A special report: suggested procedures for international unrelated donor search from the donor regis...
Next Document:  High-dose chemotherapy with autologous peripheral blood stem cell transplantation for bone and soft-...