| Impact of cinacalcet hydrochloride on bone histology in patients with secondary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 19032526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum parathyroid hormone (PTH) levels are effectively decreased by cinacalcet hydrochloride (HCl) in patients with secondary hyperparathyroidism. We assessed the impact of cinacalcet HCl on bone histology in these patients. Four hemodialysis patients with secondary hyperparathyroidism (intact PTH > or = 300 pg/mL) were treated with cinacalcet HCl with low-doses of vitamin D sterols as well as calcium-based phosphate binders for 52 weeks. Patients 1, 2, 3 and 4 were aged 55, 65, 61 and 70 years old, and the duration of hemodialysis in the patients was 84, 176, 125 and 216 months, respectively. Serum intact PTH, serum bone metabolism markers and bone histomorphometric parameters were determined before and after 52 weeks of the treatment. Serum intact PTH decreased from 1110, 880, 330 and 980 pg/mL to 233, 80, 88 and 116 pg/mL, respectively, in the four patients after 52 weeks of treatment with cinacalcet HCl. Serum levels of bone metabolism markers and all of the histomorphometric resorption parameters decreased in these patients. In particular, fibrosis volume decreased to 0% in all of the patients. Static formation parameters, including osteoblast surface and osteoid-related parameters, all decreased after the treatment, indicating an increase of mineralized bone volume during the treatment. Dynamic parameters except for activation frequency decreased after the treatment, indicating significant suppression of bone turnover. Cinacalcet HCl with low-doses of vitamin D sterols suppressed serum PTH with no significant changes of serum calcium levels. In addition, long-term administration of cinacalcet HCl improved hyperparathyroid bone diseases in patients with secondary hyperparathyroidism. |
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Authors:
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Aiji Yajima; Tadao Akizawa; Yusuke Tsukamoto; Satoshi Kurihara; Akemi Ito; |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 12 Suppl 1 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-26 Completed Date: 2009-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: S38-43 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Towa Hospital, Tokyo, Japan. a-and-y@rj8.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone and Bones / drug effects*, metabolism Calcium / blood Drug Therapy, Combination Fibrosis / metabolism Humans Hyperparathyroidism, Secondary / drug therapy*, physiopathology Kidney Failure, Chronic / complications Middle Aged Naphthalenes / administration & dosage, pharmacology* Osteoblasts / drug effects, metabolism Parathyroid Hormone / blood Renal Dialysis* Renal Osteodystrophy / drug therapy Time Factors Vitamin D / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Naphthalenes; 0/Parathyroid Hormone; 1406-16-2/Vitamin D; 364782-34-3/cinacalcet; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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