Document Detail

Impact of chronic rhinosinusitis therapy on quality of life: a prospective randomized controlled trial.
MedLine Citation:
PMID:  21038021     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To conduct the first prospective randomized controlled trial, evaluating and comparing the effect of medical and surgical treatment of chronic rhinosinusitis (CRS) on quality of life.
MATERIALS AND METHODS: Ninety patients with CRS, who remained symptomatic after initial medical treatment with Dexarhinaspray duo and nasal douche, were randomized either to medical or surgical therapy. All patients underwent pre- and post-treatment assessments of the Sinonasal Outcome Test-20 (SNOT-20), and the Short Form 36 Health Survey (SF-36). Each patient had three assessments: before starting the randomized treatment, after six months and finally after one year.
RESULTS: Both the medical and surgical treatment of CRS significantly improved almost all the parameters of SNOT and SF-36 (p<0.05), with no significant difference being found between the medical and surgical groups (p>0.05).
CONCLUSION: Both maximal medical and surgical therapy of CRS improves the quality of life of CRS patients, providing further evidence that chronic rhinosinusitis should be targeted with maximal medical therapy in the first instance, with surgical treatment being reserved for cases refractory to medical therapy. The presence of nasal polyps does not imply any negative effect on the quality of life after CRS therapy, either medical or surgical.
Sameh M Ragab; Valerie J Lund; Glenis Scadding; Hehsam A Saleh; Mohamed A Khalifa
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-09-01
Journal Detail:
Title:  Rhinology     Volume:  48     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
Tanta University Hospitals, Tanta, Egypt.
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MeSH Terms
Chronic Disease
Health Status Indicators*
Middle Aged
Prospective Studies
Quality of Life*
Rhinitis / drug therapy*,  surgery*
Sinusitis / drug therapy*,  surgery*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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