| Impact of chronic kidney disease on the efficacy of drug-eluting stents: long-term follow-up study. | |
| | |
MedLine Citation:
|
PMID: 21503391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Patients with chronic kidney disease (CKD) submitted to coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. Drug-eluting stents (DES) are associated with a lower rate of restenosis, compared to bare metal stents (BMS), although data on DES efficacy and safety is limited in patients with CKD. OBJECTIVE: We sought to evaluate the safety and efficacy of DES in patients with significant CKD as compared to patients without normal renal function in a real world registry. METHODS: 504 patients who underwent percutaneous coronary intervention with DES in two centers were included. Outcomes were stratified based on the presence of CKD, defined as a baseline glomerular filtration rate (GFR) < 60 ml/min/1.73 m². RESULTS: The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had a higher incidence of hypertension and diabetes. CKD patients presented an increased incidence of death (12.3% vs 2.4%, p < 0.001) and myocardial infarction (MI) (7.4% vs 3.3%, p = 0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs 5.6%, p = 0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 - 19.5, p < 0.001), current smoking (HR 3.66; 1.20 - 11.10, p = 0.02) and diabetes (HR 2.66; 1.03 - 6.60, p = 0.045). CONCLUSION: In this registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates. |
| | |
Authors:
|
Vitor Osório Gomes; Patrícia Blaya; Ricardo Lasevitch; Denise Oliveira; Patrícia Hickmann; Luís Smidt; Carisi Polanczyk; Paulo Caramori |
Publication Detail:
|
Type: Journal Article; Multicenter Study Date: 2011-04-15 |
Journal Detail:
|
Title: Arquivos brasileiros de cardiologia Volume: 96 ISSN: 1678-4170 ISO Abbreviation: Arq. Bras. Cardiol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-23 Completed Date: 2011-12-07 Revised Date: 2012-03-15 |
Medline Journal Info:
|
Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: Brazil |
Other Details:
|
Languages: eng; por; spa Pagination: 346-51 Citation Subset: IM |
Affiliation:
|
Hospital São Lucas da Pontifícia Universidade, Católica do Rio Grande do Sul, Brasil. vigomes@cardiol.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Cardiovascular Diseases / mortality* Case-Control Studies Chi-Square Distribution Drug-Eluting Stents / adverse effects* Female Follow-Up Studies Glomerular Filtration Rate / physiology Humans Male Middle Aged Reference Values Renal Insufficiency, Chronic / physiopathology* Risk Factors |
| Comments/Corrections | |
Comment In:
|
Arq Bras Cardiol. 2012 Jan;98(1):95, author reply 95
[PMID:
22323325
]
|
Erratum In:
|
Arq Bras Cardiol. 2011 Jun;96(6):519 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between cardiac adrenergic image and exercise testing in heart failure.
Next Document: Quantification of left ventricular dilatation in myocardial perfusion scintigraphy.