Document Detail

Impact of chronic DDD pacing on time-domain indexes of heart rate variability in patients with hypertrophic obstructive cardiomyopathy.
MedLine Citation:
PMID:  10642136     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to examine whether DDD pacing affects time-domain indexes of heart rate variability (HRV) in patients with hypertrophic obstructive cardiomyopathy (HOCM). We studied 11 patients (7 men, age 52 +/- 8 years) with HOCM refractory to drugs. In all patients a DDD pacemaker was implanted and the atrioventricular delay was programmed to ensure a full ventricular activation sequence. Time-domain indexes of HRV (mean NN, SDANN, SDNN, SD, rMSSD, pNN50) were determined from 24-hour Holter recordings 3 days before and 1 year after pacemaker implantation. The pacemaker was turned off during the second recordings. The same indexes were determined in ten healthy controls at the same time points. The controls showed no significant differences in any of the measured parameters between the two time points. The HOCM patients showed an increase in SD (from 27 +/- 13 to 41 +/- 13 ms, P < 0.001), rMSSD (from 18 +/- 5 to 32 +/- 8 ms, P < 0.001), and pNN50 (from 1.03 +/- 1.06 to 8.52 +/- 4.84%, P < 0.0001). As a result, the values of these three parameters, which were lower in the HOCM patients than in the controls before pacing, were restored to normal levels by the end of the study. In conclusion, our findings indicate that long-term pacing in HOCM patients restores the sympathovagal balance in the heart by increasing vagal activity.
E N Simantirakis; G E Kochiadakis; M K Kanakaraki; M E Marketou; F I Parthenakis; E M Kanoupakis; P E Vardas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  22     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1808-13     Citation Subset:  IM    
Cardiology Department, University Hospital of Heraklion, Crete, Greece.
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MeSH Terms
Atrioventricular Node / physiopathology
Cardiac Pacing, Artificial / methods*
Cardiomyopathy, Hypertrophic / physiopathology,  therapy*
Echocardiography, Doppler
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Conduction System / physiopathology
Heart Rate / physiology*
Linear Models
Middle Aged
Pacemaker, Artificial / classification
Stroke Volume / physiology
Sympathetic Nervous System / physiopathology
Time Factors
Vagus Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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