Document Detail


Impact of childhood obesity on cardiac structure and function.
MedLine Citation:
PMID:  25193558     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Obesity prevalence is still on the rise worldwide in both adults and children. In adults, obesity is a significant cardiovascular risk factor associated with increased morbidity and mortality. In children and adolescents this is more controversial, but early changes in cardiovascular function have been observed with possible long-term implications. In this review, we focus on the cardiac impact of childhood obesity. Obese children have been shown to have larger left atrial and ventricular dimensions, and increased left ventricular mass compared to normal weight controls. In contrast to the adult population, heart failure and significant ventricular dysfunction with reduced ejection fraction has not been reported in obese children. Several studies suggest the presence of sub-clinical myocardial dysfunction with reduced tissue Doppler velocities and myocardial deformation (strain and strain rate) in obese children. These early myocardial changes are associated with a variety of risk factors, such as systemic hypertension, diabetes, and lipid abnormalities (metabolic syndrome). As the long-term effect of these early changes is uncertain, and only very limited data are available on the effect of weight reduction and lifestyle changes on myocardial functional parameters, no interventional strategies are currently recommended.
Authors:
Laurens P Koopman; Luc L Mertens
Related Documents :
25402428 - Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventric...
25145628 - Therapeutic silencing of mir-652 restores heart function and attenuates adverse remodel...
25191998 - Electrophysiological and structural remodeling in heart failure modulate arrhythmogenes...
9651808 - Myocardial contraction band necrosis in stranded cetaceans.
15630038 - Impaired flow-mediated dilation and risk of restenosis in patients undergoing coronary ...
15735848 - Off pump coronary artery bypass graft surgery versus conventional coronary artery bypas...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current treatment options in cardiovascular medicine     Volume:  16     ISSN:  1092-8464     ISO Abbreviation:  Curr Treat Options Cardiovasc Med     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-09-06     Completed Date:  2014-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815942     Medline TA:  Curr Treat Options Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High corn oil dietary intake improves health and longevity of aging mice.
Next Document:  Cardiovascular disease associated with the human immunodeficiency virus: an update.